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Modulation of receptors and adenylate cyclase activity during sucrose feeding, food deprivation, and cold exposure

Modulation of receptors and adenylate cyclase activity during sucrose feeding, food deprivation,... The ,&adrenergic pathway has been investigated in rats hamsters after acclimation (2, 4, 6, 7, 10, 12, 15, 21, 22, 24). After a 3-day exposure to the , there is an increase in BAT norepinephrine turnover (24). With longer exposure to the , there is a hyperplasia of BAT (4, 6, 10). Catecholamine responsiveness is diminished in BAT from -exposed animals (12). One study in rats reported a decrease in P-adrenergic receptor density (4), whereas a second study reported an increase in receptor density (15). A third study in hamsters reported no change in receptor density (21). Several other studies found a decrease in norepinephrine-stimulated adenylate cyclase activity (2, 21, 22). In contrast, there was also an increase in total adenylate cyclase activity (7,22), possibly due to an increase in the guanine nucleotide-binding regulatory protein or the catalytic unit of adenylate cyclase. In sucrose-fed rats or overfed rats (cafeteria diet) there is an increase in BAT norepinephrine turnover BAT thermogenesis (1, 9, 15, 24). Cafeteria increases the density of P-adrenergic receptors in BAT (15). The effects of sucrose on BAT p-adrenergic receptors adenylate cyclase activity are unknown. To investigate the effects of sucrose-, fasting, exposure on the P-adrenergic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Modulation of receptors and adenylate cyclase activity during sucrose feeding, food deprivation, and cold exposure

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Publisher
The American Physiological Society
Copyright
Copyright © 1987 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
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Abstract

The ,&adrenergic pathway has been investigated in rats hamsters after acclimation (2, 4, 6, 7, 10, 12, 15, 21, 22, 24). After a 3-day exposure to the , there is an increase in BAT norepinephrine turnover (24). With longer exposure to the , there is a hyperplasia of BAT (4, 6, 10). Catecholamine responsiveness is diminished in BAT from -exposed animals (12). One study in rats reported a decrease in P-adrenergic receptor density (4), whereas a second study reported an increase in receptor density (15). A third study in hamsters reported no change in receptor density (21). Several other studies found a decrease in norepinephrine-stimulated adenylate cyclase activity (2, 21, 22). In contrast, there was also an increase in total adenylate cyclase activity (7,22), possibly due to an increase in the guanine nucleotide-binding regulatory protein or the catalytic unit of adenylate cyclase. In sucrose-fed rats or overfed rats (cafeteria diet) there is an increase in BAT norepinephrine turnover BAT thermogenesis (1, 9, 15, 24). Cafeteria increases the density of P-adrenergic receptors in BAT (15). The effects of sucrose on BAT p-adrenergic receptors adenylate cyclase activity are unknown. To investigate the effects of sucrose-, fasting, exposure on the P-adrenergic

Journal

AJP - Endocrinology and Metabolism – The American Physiological Society

Published: Dec 1, 1987

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