Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Amsellem, R. Delorme, C. Souchier, C. Ojeda (1995)
Transverse‐axial tubular system in guinea pig ventricular cardiomyocyte: 3D reconstruction, quantification and its possible role in K+ accumulation‐depletion phenomenon in single cellsBiology of the Cell, 85
A. Lopatin, L. Shantz, C. Mackintosh, C. Nichols, A. Pegg (2000)
Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis.Journal of molecular and cellular cardiology, 32 11
J. Cordeiro, K. Spitzer, W. Giles, PE Ershler, M. Cannell, Jhb Bridge (2001)
Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cellsThe Journal of Physiology, 531
O. Hamill, A. Marty, E. Neher, B. Sakmann, F. Sigworth (1981)
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesPflügers Archiv, 391
R. Clark, Annie Tremblay, P. Melnyk, B. Allen, W. Giles, C. Fiset (2001)
T‐tubule localization of the inward‐rectifier K+ channel in mouse ventricular myocytes: a role in K+ accumulationThe Journal of Physiology, 537
T. Suzuki (1968)
Ultrastructural changes of heart muscle in cyanide poisoning.The Tohoku journal of experimental medicine, 95 3
C. Soeller, M. Cannell (1999)
Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques.Circulation research, 84 3
M. McLerie, A. Lopatin (2003)
Dominant-negative suppression of I(K1) in the mouse heart leads to altered cardiac excitability.Journal of molecular and cellular cardiology, 35 4
R. Kaprielian, Shirley Stevenson, S. Rothery, M. Cullen, N. Severs (2000)
Distinct patterns of dystrophin organization in myocyte sarcolemma and transverse tubules of normal and diseased human myocardium.Circulation, 101 22
Heping Cheng, M. Cannell, W. Lederer (1994)
Propagation of excitation-contraction coupling into ventricular myocytesPflügers Archiv, 428
Zhaokang Yang, C. Pascarel, Derek Steele, K. Komukai, F. Brette, C. Orchard (2002)
Na+-Ca2+ Exchange Activity Is Localized in the T-Tubules of Rat Ventricular MyocytesCirculation Research: Journal of the American Heart Association, 91
K. Komukai, F. Brette, Tomoko Yamanushi, C. Orchard (2002)
K+ current distribution in rat sub-epicardial ventricular myocytesPflügers Archiv, 444
M. Kawai, M. Hussain, C. Orchard (1999)
Excitation-contraction coupling in rat ventricular myocytes after formamide-induced detubulation.American journal of physiology. Heart and circulatory physiology, 277 2
AJP-Heart Circ Physiol @BULLET
Jia-Qiang He, M. Conklin, J. Foell, M. Wolff, R. Haworth, R. Coronado, T. Kamp (2001)
Reduction in density of transverse tubules and L-type Ca(2+) channels in canine tachycardia-induced heart failure.Cardiovascular research, 49 2
Takeharu Hayashi, M. Martone, Zeyun Yu, A. Thor, M. Doi, M. Holst, Mark Ellisman, M. Hoshijima (2009)
Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heartJournal of Cell Science, 122
J. Nerbonne, R. Kass (2005)
Molecular physiology of cardiac repolarization.Physiological reviews, 85 4
F. Brette, K. Komukai, C. Orchard (2002)
Validation of formamide as a detubulation agent in isolated rat cardiac cells.American journal of physiology. Heart and circulatory physiology, 283 4
Jun Zhou, Andreas Jeron, B. London, Xingqiang Han, Gideon Koren (1998)
Characterization of a slowly inactivating outward current in adult mouse ventricular myocytes.Circulation research, 83 8
M. Pásek, F. Brette, Adam Nelson, C. Pearce, A. Qaiser, G. Christé, Clive Orchard (2008)
Quantification of t-tubule area and protein distribution in rat cardiac ventricular myocytes.Progress in biophysics and molecular biology, 96 1-3
W. Louch, H. Mørk, Joseph Sexton, Taevje Strømme, P. Laake, I. Sjaastad, O. Sejersted (2006)
T‐tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarctionThe Journal of Physiology, 574
F. Brette, L. Sallé, C. Orchard (2004)
Differential Modulation of L-type Ca2+ Current by SR Ca2+ Release at the T-Tubules and Surface Membrane of Rat Ventricular MyocytesCirculation Research: Journal of the American Heart Association, 95
W. DuBell, W. Lederer, T. Rogers
K 1 currents responsible for repolarization in mouse ventricle and their modulation by FK-506 and rapamycin
D. Dow, K. Walton, S. Fleischer (1970)
Control of mitochondrial swelling by Mg2+—the relation of ion transport to structural changesJournal of bioenergetics, 1
J. Berlin (1995)
Spatiotemporal changes of Ca2+ during electrically evoked contractions in atrial and ventricular cells.The American journal of physiology, 269 3 Pt 2
H. Takeshima, H. Takeshima, S. Komazaki, M. Nishi, M. Nishi, M. Iino, K. Kangawa (2000)
Junctophilins: a novel family of junctional membrane complex proteins.Molecular cell, 6 1
Hao-dong Xu, Weinong Guo, J. Nerbonne (1999)
Four Kinetically Distinct Depolarization-activated K+ Currents in Adult Mouse Ventricular MyocytesThe Journal of General Physiology, 113
F. Brette, C. Orchard (2007)
Resurgence of cardiac t-tubule research.Physiology, 22
E. Savio-Galimberti, J. Frank, M. Inoue, J. Goldhaber, M. Cannell, J. Bridge, F. Sachse (2008)
Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images.Biophysical journal, 95 4
C. Fiset, R. Clark, T. Larsen, W. Giles (1997)
A rapidly activating sustained K+ current modulates repolarization and excitation–contraction coupling in adult mouse ventricleThe Journal of Physiology, 504
W. Louch, O. Sejersted, F. Swift (2010)
There Goes the Neighborhood: Pathological Alterations in T-Tubule Morphology and Consequences for Cardiomyocyte Ca2+ HandlingJournal of Biomedicine and Biotechnology, 2010
Sheng Wei, Ang Guo, Biyi Chen, W. Kutschke, Yu-Ping Xie, Kathy Zimmerman, Robert Weiss, M. Anderson, Heping Cheng, Long-Sheng Song (2010)
T-Tubule Remodeling During Transition From Hypertrophy to Heart FailureCirculation Research, 107
G. Bu, Heather Adams, E. Berbari, M. Rubart (2009)
Uniform action potential repolarization within the sarcolemma of in situ ventricular cardiomyocytes.Biophysical journal, 96 6
Abstract Cardiac ventricular myocytes possess an extensive t-tubular system that facilitates the propagation of membrane potential across the cell body. It is well established that ionic currents at the restricted t-tubular space may lead to significant changes in ion concentrations, which, in turn, may affect t-tubular membrane potential. In this study, we used the whole cell patch-clamp technique to study accumulation and depletion of t-tubular potassium by measuring inward rectifier potassium tail currents ( I K1,tail ), and inward rectifier potassium current ( I K1 ) “inactivation”. At room temperatures and in the absence of Mg 2+ ions in pipette solution, the amplitude of I K1,tail measured ∼10 min after the establishment of whole cell configuration was reduced by ∼18%, but declined nearly twofold in the presence of 1 mM cyanide. At ∼35°C I K1,tail was essentially preserved in intact cells, but its amplitude declined by ∼85% within 5 min of cell dialysis, even in the absence of cyanide. Intracellular Mg 2+ ions played protective role at all temperatures. Decline of I K1,tail was accompanied by characteristic changes in its kinetics, as well as by changes in the kinetics of I K1 inactivation, a marker of depletion of t-tubular K + . The data point to remodeling of t tubules as the primary reason for the observed effects. Consistent with this, detubulation of myocytes using formamide-induced osmotic stress significantly reduced I K1,tail , as well as the inactivation of inward I K1 . Overall, the data provide strong evidence that changes in t tubule volume/structure may occur on a short time scale in response to various types of stress. inward rectifier potassium channels cardiac myocytes Copyright © 2011 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print September 2011 , doi: 10.1152/ajpheart.00304.2011 AJP - Heart November 2011 vol. 301 no. 5 H1984-H1995 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpheart.00304.2011v1 301/5/H1984 most recent Classifications Cardiac Excitation and Contraction Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Cheng, L. Articles by Lopatin, A. N. PubMed PubMed citation Articles by Cheng, L. Articles by Lopatin, A. N. Related Content Cardiac Excitation and Contraction Load related web page information Current Issue November 2011, 301 (5) Alert me to new issues of AJP - Heart About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2011 the American Physiological Society Print ISSN: 0363-6135 Online ISSN: 1522-1539 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Nov 1, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.