I. INTRODUCTION A. Dopamine: An Intensive Subject of Research Hundreds of publications dozens of reviews conferences have been devoted to dopamine neurons over the last three decades. From mocular neurobiology to neurology psychiatry, scientists working in all the domains of research in the neurosciences, in the widest sense, have taken an interest in these neurons. Investigations in this field are still so intensive that an up-to-date review covering all the lines of research is now a chalnge for a sing group of reviewers , more practically, beyond the limited space availab in journals. Several reasons might be given to explain this great interest. The first is of a pharmacological therapeutic order. Antipsychotic (neuroptic) drugs psychostimulants were used misused before their neurobiological substrates of action were discovered, modern psychopharmacology was born with the discovery of their clinical action. The neurons 0031-9333191 $1.50 Copyright 0 1991 the American Physiological Society then turned out to be the missing link between 1) psychiatric illnesses or behavioral modifications, Z) therapeutics by sective mocus, 3) a pathogenic hypothesis of psychotic states. In parall the discovery that Parkinsonâs disease had an anatomopathological basis, specifically a sion of cells within the substantia nigra, gave rise to
Physiological Reviews – The American Physiological Society
Published: Jan 1, 1991
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