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Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair

Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair REFERENCES 1. ↵ Abu Jawdeh BG , Khan S , Deschênes I , Hoshi M , Goel M , Lock JT , Shinlapawittayatorn K , Babcock G , Lakhe-Reddy S , DeCaro G , Yadav SP , Mohan ML , Naga Prasad SV , Schilling WP , Ficker E , Schelling JR . Phosphoinositide binding differentially regulates NHE1 Na + /H + exchanger-dependent proximal tubule cell survival . J Biol Chem 286 : 42435 – 42445 , 2011 . OpenUrl Abstract / FREE Full Text 2. ↵ Akis N , Madaio MP . Isolation, culture, and characterization of endothelial cells from mouse glomeruli . Kidney Int 65 : 2223 – 2227 , 2004 . OpenUrl CrossRef Medline Web of Science 3. ↵ Barnes JL , Abboud HE . Temporal expression of autocrine growth factors corresponds to morphological features of mesangial proliferation in Habu snake venom-induced glomerulonephritis . Am J Pathol 143 : 1366 – 1376 , 1993 . OpenUrl Medline Web of Science 4. ↵ Barnes JL , Hevey KA , Hastings RR , Bocanegra RA . Mesangial cell migration precedes proliferation in Habu snake venom-induced glomerular injury . Lab Invest 70 : 460 – 467 , 1994 . OpenUrl Medline Web of Science 5. ↵ Betz UA , Vosshenrich CA , Rajewsky K , Muller W . Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination . Curr Biol 6 : 1307 – 1316 , 1996 . OpenUrl CrossRef Medline Web of Science 6. ↵ Cambier S , Gline S , Mu D , Collins R , Araya J , Dolganov G , Einheber S , Boudreau N , Nishimura SL . Integrin α v β 8 -mediated activation of transforming growth factor-β by perivascular astrocytes: an angiogenic control switch . Am J Pathol 166 : 1883 – 1894 , 2005 . OpenUrl CrossRef Medline Web of Science 7. ↵ Cambier S , Mu DZ , O'Connell D , Boylen K , Travis W , Liu WH , Broaddus VC , Nishimura SL . A role for the integrin α v β 8 in the negative regulation of epithelial cell growth . Cancer Res 60 : 7084 – 7093 , 2000 . OpenUrl Abstract / FREE Full Text 8. ↵ Cuttler AS , LeClair RJ , Stohn JP , Wang Q , Sorensson J , Liaw L , Lindner V . Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries . Genesis 49 : 673 – 680 , 2011 . OpenUrl CrossRef Medline Web of Science 9. ↵ De Gasperi R , Rocher AB , Sosa MA , Wearne SL , Perez GM , Friedrich VL Jr . , Hof PR , Elder GA . The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ . Genesis 46 : 308 – 317 , 2008 . OpenUrl CrossRef Medline Web of Science 10. ↵ Foo SS , Turner CJ , Adams S , Compagni A , Aubyn D , Kogata N , Lindblom P , Shani M , Zicha D , Adams RH . Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly . Cell 124 : 161 – 173 , 2006 . OpenUrl CrossRef Medline Web of Science 11. ↵ Gauer S , Yao J , Schoecklmann HO , Sterzel RB . Adhesion molecules in the glomerular mesangium . Kidney Int 51 : 1447 – 1453 , 1997 . OpenUrl CrossRef Medline Web of Science 12. ↵ Gurley SB , Clare SE , Snow KP , Hu A , Meyer TW , Coffman TM . Impact of genetic background on nephropathy in diabetic mice . Am J Physiol Renal Physiol 290 : F214 – F222 , 2006 . OpenUrl Abstract / FREE Full Text 13. ↵ Haas CS , Amann K , Schittny J , Blaser B , Müller U , Hartner A . Glomerular and renal vascular structural changes in α8 integrin-deficient mice . J Am Soc Nephrol 14 : 2288 – 2296 , 2003 . OpenUrl Abstract / FREE Full Text 14. ↵ Hall A . Rho family GTPases . Biochem Soc Trans 40 : 1378 – 1382 , 2012 . OpenUrl CrossRef Medline Web of Science 15. ↵ Hartner A , Marek I , Cordasic N , Haas C , Schocklmann H , Hulsmann-Volkert G , Plasa I , Rascher W , Hilgers KF , Amann K . Glomerular regeneration is delayed in nephritic α 8 -integrin-deficient mice: contribution of α 8 -integrin to the regulation of mesangial cell apoptosis . Am J Nephrol 28 : 168 – 178 , 2007 . OpenUrl 16. ↵ Heptinstall RH . Classification of glomerulonephritis; focal and proliferative forms . In: Pathology of the Kidney . Boston, MA : Little, Brown, and Company , 1992 , p. 261 – 296 . 17. ↵ Heymann F , Meyer-Schwesinger C , Hamilton-Williams EE , Hammerich L , Panzer U , Kaden S , Quaggin SE , Floege J , Grone HJ , Kurts C . Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury . J Clin Invest 119 : 1286 – 1297 , 2009 . OpenUrl CrossRef Medline Web of Science 18. ↵ Hugo C , Shankland SJ , Bowen-Pope DF , Couser WG , Johnson RJ . Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus . J Clin Invest 100 : 786 – 794 , 1997 . OpenUrl CrossRef Medline Web of Science 19. ↵ Jarad G , Wang B , Khan S , DeVore J , Miao H , Wu K , Nishimura SL , Wible BA , Konieczkowski M , Sedor JR , Schelling JR . Fas activation induces renal tubular epithelial cell β8 integrin expression and function in the absence of apoptosis . J Biol Chem 277 : 47826 – 47833 , 2002 . OpenUrl Abstract / FREE Full Text 20. ↵ Johnstone DB , Ikizler O , Zhang J , Holzman LB . Background strain and the differential susceptibility of podocyte-specific deletion of Myh9 on murine models of experimental glomerulosclerosis and HIV nephropathy . PLOS ONE 8 : e67839 , 2013 . OpenUrl CrossRef 21. ↵ Keppler A , Gretz N , Schmidt R , Kloetzer HM , Groene HJ , Lelongt B , Meyer M , Sadick M , Pill J . Plasma creatinine determination in mice and rats: an enzymatic method compares favorably with a high-performance liquid chromatography assay . Kidney Int 71 : 74 – 78 , 2007 . OpenUrl CrossRef Medline Web of Science 22. ↵ Khan S , Lakhe-Reddy S , McCarty JH , Sorenson CM , Sheibani N , Reichardt LF , Kim JH , Wang B , Sedor JR , Schelling JR . Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1 . Am J Pathol 178 : 609 – 620 , 2011 . OpenUrl CrossRef Medline Web of Science 23. ↵ Khan S , Wu KL , Sedor JR , Abu Jawdeh BG , Schelling JR . The NHE1 Na + /H + exchanger regulates cell survival by activating and targeting ezrin to specific plasma membrane domains . Cell Mol Biol 52 : 115 – 121 , 2006 . OpenUrl Medline 24. ↵ Kikkawa Y , Virtanen I , Miner JH . Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin α 5 in the glomerular basement membrane . J Cell Biol 161 : 187 – 196 , 2003 . OpenUrl Abstract / FREE Full Text 25. ↵ Lakhe-Reddy S , Khan S , Konieczkowski M , Jarad G , Wu KL , Reichardt LF , Takai Y , Bruggeman LA , Wang B , Sedor JR , Schelling JR . β 8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation . J Biol Chem 281 : 19688 – 19699 , 2006 . OpenUrl Abstract / FREE Full Text 26. ↵ Langhofer M , Hopkinson SB , Jones JC . The matrix secreted by 804G cells contains laminin-related components that participate in hemidesmosome assembly in vitro . J Cell Sci 105 : 753 – 764 , 1993 . OpenUrl Abstract / FREE Full Text 27. ↵ Leveen P , Pekny M , Gebre-Medhin S , Swolin B , Larsson E , Betsholtz C . Mice deficient for PDGF-B show renal, cardiovascular, and hematological abnormalities . Genes Dev 8 : 1875 – 1887 , 1994 . OpenUrl Abstract / FREE Full Text 28. ↵ McCarty JH , Lacy-Hulbert A , Charest A , Bronson RT , Crowley D , Housman D , Savill J , Roes J , Hynes RO . Selective ablation of α v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death . Development 132 : 165 – 176 , 2005 . OpenUrl Abstract / FREE Full Text 29. ↵ McCarty JH , Monahan-Earley RA , Brown LF , Keller M , Gerhardt H , Rubin K , Shani M , Dvorak HF , Wolburg H , Bader BL , Dvorak AM , Hynes RO . Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking α v integrins . Mol Cell Biol 22 : 7667 – 7677 , 2002 . OpenUrl Abstract / FREE Full Text 30. ↵ Moyle M , Napier MA , McLean JW . Cloning and expression of a divergent integrin subunit β8 . J Biol Chem 266 : 19650 – 19658 , 1991 . OpenUrl Abstract / FREE Full Text 31. ↵ Mu D , Cambier S , Fjellbirkeland L , Baron JL , Munger JS , Kawakatsu H , Sheppard D , Broaddus VC , Nishimura SL . The integrin α v β 8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1 . J Cell Biol 157 : 493 – 507 , 2002 . OpenUrl Abstract / FREE Full Text 32. ↵ Proctor JM , Zang K , Wang D , Wang R , Reichardt LF . Vascular development of the brain requires β 8 integrin expression in the neuroepithelium . J Neurosci 25 : 9940 – 9948 , 2005 . OpenUrl Abstract / FREE Full Text 33. ↵ Roca-Cusachs P , Iskratsch T , Sheetz MP . Finding the weakest link: exploring integrin-mediated mechanical molecular pathways . J Cell Sci 125 : 3025 – 3038 , 2012 . OpenUrl Abstract / FREE Full Text 34. ↵ Schelling JR , Nkemere N , Kopp JB , Cleveland RP . Fas-dependent fratricidal apoptosis is a mechanism of tubular epithelial cell deletion in chronic renal failure . Lab Invest 78 : 813 – 824 , 1998 . OpenUrl Medline Web of Science 35. ↵ Schulz TJ , Glaubitz M , Kuhlow D , Thierbach R , Birringer M , Steinberg P , Pfeiffer AF , Ristow M . Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping . PLOS ONE 2 : e1013 , 2007 . OpenUrl CrossRef Medline 36. ↵ Schvartz I , Seger D , Shaltiel S . Vitronectin . Int J Biochem Cell Biol 31 : 539 – 544 , 1999 . OpenUrl CrossRef Medline Web of Science 37. ↵ Sedor JR . Cytokines, kidney disease, and therapy: a molecular characterization provides insights into mechanism . J Lab Clin Med 124 : 470 – 472 , 1994 . OpenUrl Medline 38. ↵ Segerer S , Heller F , Lindenmeyer MT , Schmid H , Cohen CD , Draganovici D , Mandelbaum J , Nelson PJ , Grone HJ , Grone EF , Figel AM , Nossner E , Schlondorff D . Compartment specific expression of dendritic cell markers in human glomerulonephritis . Kidney Int 74 : 37 – 46 , 2008 . OpenUrl CrossRef Medline Web of Science 39. ↵ Seiffert D , Crain K , Wagner NV , Loskutoff DJ . Vitronectin gene expression in vivo. Evidence for extrahepatic synthesis and acute phase regulation . J Biol Chem 269 : 19836 – 19842 , 1994 . OpenUrl Abstract / FREE Full Text 40. ↵ Sequeira Lopez ML , Pentz ES , Nomasa T , Smithies O , Gomez RA . Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened . Dev Cell 6 : 719 – 728 , 2004 . OpenUrl CrossRef Medline Web of Science 41. ↵ Soriano P . Abnormal kidney development and hematological disorders in PDGFβ-receptor mutant mice . Genes Dev 8 : 1888 – 1896 , 1994 . OpenUrl Abstract / FREE Full Text 42. ↵ Srichai MB , Konieczkowski M , Padiyar A , Konieczkowski DJ , Mukherjee A , Hayden PS , Kamat S , El Meanawy MA , Khan S , Mundel P , Lee SB , Bruggeman LA , Schelling JR , Sedor JR . A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus . J Biol Chem 279 : 14398 – 14408 , 2004 . OpenUrl Abstract / FREE Full Text 43. ↵ Stahl RA , Thaiss F , Wenzel U , Helmchen U . Morphologic and functional consequences of immune-mediated mesangiolysis: development of chronic glomerular sclerosis . J Am Soc Nephrol 2 : S144 – S148 , 1992 . OpenUrl Abstract 44. ↵ Travis MA , Reizis B , Melton AC , Masteller E , Tang Q , Proctor JM , Wang Y , Bernstein X , Huang X , Reichardt LF , Bluestone JA , Sheppard D . Loss of integrin α v β 8 on dendritic cells causes autoimmunity and colitis in mice . Nature 449 : 361 – 365 , 2007 . OpenUrl CrossRef Medline Web of Science 45. ↵ Venstrom K , Reichardt L . β 8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin . Mol Biol Cell 6 : 419 – 431 , 1995 . OpenUrl Abstract / FREE Full Text 46. ↵ Vooijs M , Jonkers J , Berns A . A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent . EMBO Rep 2 : 292 – 297 , 2001 . OpenUrl Abstract / FREE Full Text 47. ↵ Wada T , Shimizu M , Yokoyama H , Iwata Y , Sakai Y , Kaneko S , Furuichi K . Nodular lesions and mesangiolysis in diabetic nephropathy . Clin Exp Nephrol 17 : 3 – 9 , 2013 . OpenUrl CrossRef Medline 48. ↵ Weis B , Schmidt J , Lyko F , Linhart HG . Analysis of conditional gene deletion using probe based real-time PCR . BMC Biotechnol 10 : 75 , 2010 . OpenUrl CrossRef Medline 49. ↵ Zhang Z , Morla AO , Vuori K , Bauer JS , Juliano RL , Ruoslahti E . The α v β 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin . J Cell Biol 122 : 235 – 242 , 1993 . OpenUrl Abstract / FREE Full Text 50. ↵ Zhu JW , Motejlek K , Wang DN , Zang KL , Schmidt A , Reichardt LF . β 8 integrins are required for vascular morphogenesis in mouse embryos . Development 129 : 2891 – 2903 , 2002 . OpenUrl Medline Web of Science Previous Next Back to top About the Cover About the Cover Cover image Image 1: Xin Zhang, Zi-Lun Li, John R Woollard, Alfonso Eirin, Behzad Ebrahimi, John A Crane, Xiang- Yang Zhu, Aditya Pawar, James D Krier, Kyra L. Jordan, Hui Tang, Stephen C. Textor, Amir Lerman, and Lilach O. Lerman. Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00043.2013. Image 2: Yun-Hee Choi, Brian T. McNally, and Peter Igarashi. Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1β . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00582.2012. Image 3: Soundarapandian Vijayakumar, Hu Peng, and George J Schwartz. Galectin-3 mediates oligomerization of secreted hensin using its carbohydrate recognition domain . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00498.2012. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords cell migration extracellular matrix glomerular endothelial cell glomerular injury Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Renal Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair Message Subject (Your Name) has sent you a message from Renal Physiology Message Body (Your Name) thought you would like to see the Renal Physiology web site. Your Personal Message Print Citation Tools Mesangial cell α v β 8 -integrin regulates glomerular capillary integrity and repair Sujata Lakhe-Reddy , Vincent Li , Thomas D. Arnold , Shenaz Khan , Jeffrey R. Schelling American Journal of Physiology - Renal Physiology Jun 2014, 306 (12) F1400-F1409; DOI: 10.1152/ajprenal.00624.2013 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share Mesangial cell α v β 8 -integrin regulates glomerular capillary integrity and repair Mesangial cell α v β 8 -integrin regulates glomerular capillary integrity and repair Sujata Lakhe-Reddy , Vincent Li , Thomas D. Arnold , Shenaz Khan , Jeffrey R. Schelling American Journal of Physiology - Renal Physiology Jun 2014, 306 (12) F1400-F1409; DOI: 10.1152/ajprenal.00624.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria Show more Articles Related Articles No related articles found. 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Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair

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References (48)

Publisher
The American Physiological Society
Copyright
Copyright © 2014 the American Physiological Society
ISSN
0363-6127
eISSN
1522-1466
DOI
10.1152/ajprenal.00624.2013
pmid
24740792
Publisher site
See Article on Publisher Site

Abstract

REFERENCES 1. ↵ Abu Jawdeh BG , Khan S , Deschênes I , Hoshi M , Goel M , Lock JT , Shinlapawittayatorn K , Babcock G , Lakhe-Reddy S , DeCaro G , Yadav SP , Mohan ML , Naga Prasad SV , Schilling WP , Ficker E , Schelling JR . Phosphoinositide binding differentially regulates NHE1 Na + /H + exchanger-dependent proximal tubule cell survival . J Biol Chem 286 : 42435 – 42445 , 2011 . OpenUrl Abstract / FREE Full Text 2. ↵ Akis N , Madaio MP . Isolation, culture, and characterization of endothelial cells from mouse glomeruli . Kidney Int 65 : 2223 – 2227 , 2004 . OpenUrl CrossRef Medline Web of Science 3. ↵ Barnes JL , Abboud HE . Temporal expression of autocrine growth factors corresponds to morphological features of mesangial proliferation in Habu snake venom-induced glomerulonephritis . Am J Pathol 143 : 1366 – 1376 , 1993 . OpenUrl Medline Web of Science 4. ↵ Barnes JL , Hevey KA , Hastings RR , Bocanegra RA . Mesangial cell migration precedes proliferation in Habu snake venom-induced glomerular injury . Lab Invest 70 : 460 – 467 , 1994 . OpenUrl Medline Web of Science 5. ↵ Betz UA , Vosshenrich CA , Rajewsky K , Muller W . Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination . Curr Biol 6 : 1307 – 1316 , 1996 . OpenUrl CrossRef Medline Web of Science 6. ↵ Cambier S , Gline S , Mu D , Collins R , Araya J , Dolganov G , Einheber S , Boudreau N , Nishimura SL . Integrin α v β 8 -mediated activation of transforming growth factor-β by perivascular astrocytes: an angiogenic control switch . Am J Pathol 166 : 1883 – 1894 , 2005 . OpenUrl CrossRef Medline Web of Science 7. ↵ Cambier S , Mu DZ , O'Connell D , Boylen K , Travis W , Liu WH , Broaddus VC , Nishimura SL . A role for the integrin α v β 8 in the negative regulation of epithelial cell growth . Cancer Res 60 : 7084 – 7093 , 2000 . OpenUrl Abstract / FREE Full Text 8. ↵ Cuttler AS , LeClair RJ , Stohn JP , Wang Q , Sorensson J , Liaw L , Lindner V . Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries . Genesis 49 : 673 – 680 , 2011 . OpenUrl CrossRef Medline Web of Science 9. ↵ De Gasperi R , Rocher AB , Sosa MA , Wearne SL , Perez GM , Friedrich VL Jr . , Hof PR , Elder GA . The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ . Genesis 46 : 308 – 317 , 2008 . OpenUrl CrossRef Medline Web of Science 10. ↵ Foo SS , Turner CJ , Adams S , Compagni A , Aubyn D , Kogata N , Lindblom P , Shani M , Zicha D , Adams RH . Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly . Cell 124 : 161 – 173 , 2006 . OpenUrl CrossRef Medline Web of Science 11. ↵ Gauer S , Yao J , Schoecklmann HO , Sterzel RB . Adhesion molecules in the glomerular mesangium . Kidney Int 51 : 1447 – 1453 , 1997 . OpenUrl CrossRef Medline Web of Science 12. ↵ Gurley SB , Clare SE , Snow KP , Hu A , Meyer TW , Coffman TM . Impact of genetic background on nephropathy in diabetic mice . Am J Physiol Renal Physiol 290 : F214 – F222 , 2006 . OpenUrl Abstract / FREE Full Text 13. ↵ Haas CS , Amann K , Schittny J , Blaser B , Müller U , Hartner A . Glomerular and renal vascular structural changes in α8 integrin-deficient mice . J Am Soc Nephrol 14 : 2288 – 2296 , 2003 . OpenUrl Abstract / FREE Full Text 14. ↵ Hall A . Rho family GTPases . Biochem Soc Trans 40 : 1378 – 1382 , 2012 . OpenUrl CrossRef Medline Web of Science 15. ↵ Hartner A , Marek I , Cordasic N , Haas C , Schocklmann H , Hulsmann-Volkert G , Plasa I , Rascher W , Hilgers KF , Amann K . Glomerular regeneration is delayed in nephritic α 8 -integrin-deficient mice: contribution of α 8 -integrin to the regulation of mesangial cell apoptosis . Am J Nephrol 28 : 168 – 178 , 2007 . OpenUrl 16. ↵ Heptinstall RH . Classification of glomerulonephritis; focal and proliferative forms . In: Pathology of the Kidney . Boston, MA : Little, Brown, and Company , 1992 , p. 261 – 296 . 17. ↵ Heymann F , Meyer-Schwesinger C , Hamilton-Williams EE , Hammerich L , Panzer U , Kaden S , Quaggin SE , Floege J , Grone HJ , Kurts C . Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury . J Clin Invest 119 : 1286 – 1297 , 2009 . OpenUrl CrossRef Medline Web of Science 18. ↵ Hugo C , Shankland SJ , Bowen-Pope DF , Couser WG , Johnson RJ . Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus . J Clin Invest 100 : 786 – 794 , 1997 . OpenUrl CrossRef Medline Web of Science 19. ↵ Jarad G , Wang B , Khan S , DeVore J , Miao H , Wu K , Nishimura SL , Wible BA , Konieczkowski M , Sedor JR , Schelling JR . Fas activation induces renal tubular epithelial cell β8 integrin expression and function in the absence of apoptosis . J Biol Chem 277 : 47826 – 47833 , 2002 . OpenUrl Abstract / FREE Full Text 20. ↵ Johnstone DB , Ikizler O , Zhang J , Holzman LB . Background strain and the differential susceptibility of podocyte-specific deletion of Myh9 on murine models of experimental glomerulosclerosis and HIV nephropathy . PLOS ONE 8 : e67839 , 2013 . OpenUrl CrossRef 21. ↵ Keppler A , Gretz N , Schmidt R , Kloetzer HM , Groene HJ , Lelongt B , Meyer M , Sadick M , Pill J . Plasma creatinine determination in mice and rats: an enzymatic method compares favorably with a high-performance liquid chromatography assay . Kidney Int 71 : 74 – 78 , 2007 . OpenUrl CrossRef Medline Web of Science 22. ↵ Khan S , Lakhe-Reddy S , McCarty JH , Sorenson CM , Sheibani N , Reichardt LF , Kim JH , Wang B , Sedor JR , Schelling JR . Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1 . Am J Pathol 178 : 609 – 620 , 2011 . OpenUrl CrossRef Medline Web of Science 23. ↵ Khan S , Wu KL , Sedor JR , Abu Jawdeh BG , Schelling JR . The NHE1 Na + /H + exchanger regulates cell survival by activating and targeting ezrin to specific plasma membrane domains . Cell Mol Biol 52 : 115 – 121 , 2006 . OpenUrl Medline 24. ↵ Kikkawa Y , Virtanen I , Miner JH . Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin α 5 in the glomerular basement membrane . J Cell Biol 161 : 187 – 196 , 2003 . OpenUrl Abstract / FREE Full Text 25. ↵ Lakhe-Reddy S , Khan S , Konieczkowski M , Jarad G , Wu KL , Reichardt LF , Takai Y , Bruggeman LA , Wang B , Sedor JR , Schelling JR . β 8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation . J Biol Chem 281 : 19688 – 19699 , 2006 . OpenUrl Abstract / FREE Full Text 26. ↵ Langhofer M , Hopkinson SB , Jones JC . The matrix secreted by 804G cells contains laminin-related components that participate in hemidesmosome assembly in vitro . J Cell Sci 105 : 753 – 764 , 1993 . OpenUrl Abstract / FREE Full Text 27. ↵ Leveen P , Pekny M , Gebre-Medhin S , Swolin B , Larsson E , Betsholtz C . Mice deficient for PDGF-B show renal, cardiovascular, and hematological abnormalities . Genes Dev 8 : 1875 – 1887 , 1994 . OpenUrl Abstract / FREE Full Text 28. ↵ McCarty JH , Lacy-Hulbert A , Charest A , Bronson RT , Crowley D , Housman D , Savill J , Roes J , Hynes RO . Selective ablation of α v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death . Development 132 : 165 – 176 , 2005 . OpenUrl Abstract / FREE Full Text 29. ↵ McCarty JH , Monahan-Earley RA , Brown LF , Keller M , Gerhardt H , Rubin K , Shani M , Dvorak HF , Wolburg H , Bader BL , Dvorak AM , Hynes RO . Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking α v integrins . Mol Cell Biol 22 : 7667 – 7677 , 2002 . OpenUrl Abstract / FREE Full Text 30. ↵ Moyle M , Napier MA , McLean JW . Cloning and expression of a divergent integrin subunit β8 . J Biol Chem 266 : 19650 – 19658 , 1991 . OpenUrl Abstract / FREE Full Text 31. ↵ Mu D , Cambier S , Fjellbirkeland L , Baron JL , Munger JS , Kawakatsu H , Sheppard D , Broaddus VC , Nishimura SL . The integrin α v β 8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1 . J Cell Biol 157 : 493 – 507 , 2002 . OpenUrl Abstract / FREE Full Text 32. ↵ Proctor JM , Zang K , Wang D , Wang R , Reichardt LF . Vascular development of the brain requires β 8 integrin expression in the neuroepithelium . J Neurosci 25 : 9940 – 9948 , 2005 . OpenUrl Abstract / FREE Full Text 33. ↵ Roca-Cusachs P , Iskratsch T , Sheetz MP . Finding the weakest link: exploring integrin-mediated mechanical molecular pathways . J Cell Sci 125 : 3025 – 3038 , 2012 . OpenUrl Abstract / FREE Full Text 34. ↵ Schelling JR , Nkemere N , Kopp JB , Cleveland RP . Fas-dependent fratricidal apoptosis is a mechanism of tubular epithelial cell deletion in chronic renal failure . Lab Invest 78 : 813 – 824 , 1998 . OpenUrl Medline Web of Science 35. ↵ Schulz TJ , Glaubitz M , Kuhlow D , Thierbach R , Birringer M , Steinberg P , Pfeiffer AF , Ristow M . Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping . PLOS ONE 2 : e1013 , 2007 . OpenUrl CrossRef Medline 36. ↵ Schvartz I , Seger D , Shaltiel S . Vitronectin . Int J Biochem Cell Biol 31 : 539 – 544 , 1999 . OpenUrl CrossRef Medline Web of Science 37. ↵ Sedor JR . Cytokines, kidney disease, and therapy: a molecular characterization provides insights into mechanism . J Lab Clin Med 124 : 470 – 472 , 1994 . OpenUrl Medline 38. ↵ Segerer S , Heller F , Lindenmeyer MT , Schmid H , Cohen CD , Draganovici D , Mandelbaum J , Nelson PJ , Grone HJ , Grone EF , Figel AM , Nossner E , Schlondorff D . Compartment specific expression of dendritic cell markers in human glomerulonephritis . Kidney Int 74 : 37 – 46 , 2008 . OpenUrl CrossRef Medline Web of Science 39. ↵ Seiffert D , Crain K , Wagner NV , Loskutoff DJ . Vitronectin gene expression in vivo. Evidence for extrahepatic synthesis and acute phase regulation . J Biol Chem 269 : 19836 – 19842 , 1994 . OpenUrl Abstract / FREE Full Text 40. ↵ Sequeira Lopez ML , Pentz ES , Nomasa T , Smithies O , Gomez RA . 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Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords cell migration extracellular matrix glomerular endothelial cell glomerular injury Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Renal Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair Message Subject (Your Name) has sent you a message from Renal Physiology Message Body (Your Name) thought you would like to see the Renal Physiology web site. Your Personal Message Print Citation Tools Mesangial cell α v β 8 -integrin regulates glomerular capillary integrity and repair Sujata Lakhe-Reddy , Vincent Li , Thomas D. Arnold , Shenaz Khan , Jeffrey R. Schelling American Journal of Physiology - Renal Physiology Jun 2014, 306 (12) F1400-F1409; DOI: 10.1152/ajprenal.00624.2013 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share Mesangial cell α v β 8 -integrin regulates glomerular capillary integrity and repair Mesangial cell α v β 8 -integrin regulates glomerular capillary integrity and repair Sujata Lakhe-Reddy , Vincent Li , Thomas D. Arnold , Shenaz Khan , Jeffrey R. Schelling American Journal of Physiology - Renal Physiology Jun 2014, 306 (12) F1400-F1409; DOI: 10.1152/ajprenal.00624.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria Show more Articles Related Articles No related articles found. 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Published: Jun 15, 2014

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