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S. Cambier, Stephanie Gline, D. Mu, Rodney Collins, J. Araya, G. Dolganov, S. Einheber, N. Boudreau, S. Nishimura (2005)
Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β by Perivascular Astrocytes: An Angiogenic Control SwitchAmerican Journal of Pathology, 166
U. Betz, C. Vosshenrich, K. Rajewsky, Werner Müller (1996)
Bypass of lethality with mosaic mice generated by Cre–loxP-mediated recombinationCurrent Biology, 6
Shenaz Khan, S. Lakhe-Reddy, J. McCarty, C. Sorenson, N. Sheibani, L. Reichardt, Jane Kim, Bingcheng Wang, J. Sedor, J. Schelling (2011)
Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1.The American journal of pathology, 178 2
J. Proctor, K. Zang, Denan Wang, Rong Wang, L. Reichardt (2005)
Vascular Development of the Brain Requires β8 Integrin Expression in the NeuroepitheliumThe Journal of Neuroscience, 25
C. Haas, K. Amann, J. Schittny, Barbara Blaser, U. Müller, A. Hartner (2003)
Glomerular and Renal Vascular Structural Changes in α8 Integrin-Deficient MiceJournal of The American Society of Nephrology, 14
D. Mu, S. Cambier, L. Fjellbirkeland, J. Baron, J. Munger, H. Kawakatsu, D. Sheppard, V. Broaddus, S. Nishimura (2002)
The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1The Journal of Cell Biology, 157
Anne Cuttler, R. LeClair, J. Stohn, Qiaozeng Wang, C. Sorenson, L. Liaw, V. Lindner (2011)
Characterization of Pdgfrb‐Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteriesgenesis, 49
M. Travis, B. Reizis, A. Melton, E. Masteller, Q. Tang, J. Proctor, Yanli Wang, X. Bernstein, Xiaozhu Huang, L. Reichardt, J. Bluestone, D. Sheppard (2007)
Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in miceNature, 449
Y. Kikkawa, I. Virtanen, J. Miner (2003)
Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin α5 in the glomerular basement membraneThe Journal of Cell Biology, 161
R. Gasperi, A. Rocher, M. Sosa, S. Wearne, G. Perez, V. Friedrich, P. Hof, G. Elder (2008)
The IRG mouse: A two‐color fluorescent reporter for assessing Cre‐mediated recombination and imaging complex cellular relationships in situgenesis, 46
Britta Weis, J. Schmidt, F. Lyko, H. Linhart (2010)
Analysis of conditional gene deletion using probe based Real-Time PCRBMC Biotechnology, 10
Pere Roca-Cusachs, T. Iskratsch, M. Sheetz (2012)
Finding the weakest link – exploring integrin-mediated mechanical molecular pathwaysJournal of Cell Science, 125
S. Gauer, J. Yao, H. Schoecklmann, R. Sterzel (1997)
Adhesion molecules in the glomerular mesangium.Kidney international, 51 5
Philippe Soriano (1994)
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.Genes & development, 8 16
J. Barnes, H. Abboud (1993)
Temporal expression of autocrine growth factors corresponds to morphological features of mesangial proliferation in Habu snake venom-induced glomerulonephritis.The American journal of pathology, 143 5
B. Jawdeh, Shenaz Khan, I. Deschênes, M. Hoshi, Monu Goel, J. Lock, Krekwit Shinlapawittayatorn, Gerald Babcock, S. Lakhe-Reddy, G. Decaro, S. Yadav, M. Mohan, S. Prasad, W. Schilling, E. Ficker, J. Schelling (2011)
Phosphoinositide Binding Differentially Regulates NHE1 Na+/H+ Exchanger-dependent Proximal Tubule Cell Survival*The Journal of Biological Chemistry, 286
D. Seiffert, K. Crain, N. Wagner, D. Loskutoff (1994)
Vitronectin gene expression in vivo. Evidence for extrahepatic synthesis and acute phase regulation.The Journal of biological chemistry, 269 31
J. Barnes, K. Hevey, R. Hastings, R. Bocanegra (1994)
Mesangial cell migration precedes proliferation in Habu snake venom-induced glomerular injury.Laboratory investigation; a journal of technical methods and pathology, 70 4
Mikayo Langhofer, S. Hopkinson, Jonathan Jones (1993)
The matrix secreted by 804G cells contains laminin-related components that participate in hemidesmosome assembly in vitro.Journal of cell science, 105 ( Pt 3)
S. Lakhe-Reddy, Shenaz Khan, M. Konieczkowski, G. Jarad, Karen Wu, L. Reichardt, Y. Takai, L. Bruggeman, Bingcheng Wang, J. Sedor, J. Schelling (2006)
β8 Integrin Binds Rho GDP Dissociation Inhibitor-1 and Activates Rac1 to Inhibit Mesangial Cell Myofibroblast Differentiation*Journal of Biological Chemistry, 281
A. Hall (2012)
Rho family GTPases.Biochemical Society transactions, 40 6
M. Vooijs, J. Jonkers, A. Berns (2001)
A highly efficient ligand‐regulated Cre recombinase mouse line shows that LoxP recombination is position dependentEMBO reports, 2
J. McCarty, R. Monahan-Earley, L. Brown, M. Keller, H. Gerhardt, K. Rubin, M. Shani, H. Dvorak, H. Wolburg, B. Bader, A. Dvorak, R. Hynes (2002)
Defective Associations between Blood Vessels and Brain Parenchyma Lead to Cerebral Hemorrhage in Mice Lacking αv IntegrinsMolecular and Cellular Biology, 22
S. Gurley, S. Clare, Kamie Snow, A. Hu, T. Meyer, T. Coffman (2006)
Impact of genetic background on nephropathy in diabetic mice.American journal of physiology. Renal physiology, 290 1
T. Schulz, M. Glaubitz, Doreen Kuhlow, René Thierbach, M. Birringer, P. Steinberg, A. Pfeiffer, M. Ristow (2007)
Variable Expression of Cre Recombinase Transgenes Precludes Reliable Prediction of Tissue-Specific Gene Disruption by Tail-Biopsy GenotypingPLoS ONE, 2
M. Srichai, M. Konieczkowski, A. Padiyar, D. Konieczkowski, A. Mukherjee, Patrick Hayden, S. Kamat, M. El-Meanawy, Shenaz Khan, P. Mundel, Sean Lee, L. Bruggeman, J. Schelling, J. Sedor (2004)
A WT1 Co-regulator Controls Podocyte Phenotype by Shuttling between Adhesion Structures and Nucleus*Journal of Biological Chemistry, 279
K. Venstrom, L. Reichardt (1995)
Beta 8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin.Molecular biology of the cell, 6 4
Per Lev, M. Pekny, S. Gebre-Medhin, B. Swolin, E. Larsson, C. Betsholtz (1994)
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.Genes & development, 8 16
Jiangwen Zhu, K. Motejlek, Denan Wang, K. Zang, A. Schmidt, L. Reichardt (2002)
beta8 integrins are required for vascular morphogenesis in mouse embryos.Development, 129 12
D. Johnstone, O. Ikizler, Jidong Zhang, L. Holzman (2013)
Background Strain and the Differential Susceptibility of Podocyte-Specific Deletion of Myh9 on Murine Models of Experimental Glomerulosclerosis and HIV NephropathyPLoS ONE, 8
M. Moyle, M. Napier, J. McLean (1991)
Cloning and expression of a divergent integrin subunit beta 8.The Journal of biological chemistry, 266 29
S. Foo, Christopher Turner, Susanne Adams, A. Compagni, Deborah Aubyn, Naoko Kogata, P. Lindblom, M. Shani, D. Zicha, R. Adams (2006)
Ephrin-B2 Controls Cell Motility and Adhesion during Blood-Vessel-Wall AssemblyCell, 124
R. Stahl, F. Thaiss, U. Wenzel, U. Helmchen (1992)
Morphologic and functional consequences of immune-mediated mesangiolysis: development of chronic glomerular sclerosis.Journal of the American Society of Nephrology : JASN, 2 10 Suppl
F. Heymann, C. Meyer-Schwesinger, Emma Hamilton-Williams, L. Hammerich, U. Panzer, S. Kaden, S. Quaggin, J. Floege, H. Gröne, C. Kurts (2009)
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.The Journal of clinical investigation, 119 5
J. McCarty, A. Lacy-Hulbert, A. Charest, R. Bronson, D. Crowley, D. Housman, J. Savill, J. Roes, R. Hynes (2004)
Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death, 132
S. Khan, K. Wu, J. Sedor, B. Jawdeh, J. Schelling (2006)
The NHE1 Na+/H+ exchanger regulates cell survival by activating and targeting ezrin to specific plasma membrane domains.Cellular and molecular biology, 52 8
S. Cambier, D. Mu, D. O’Connell, K. Boylen, W. Travis, Wei-hong Liu, V. Broaddus, S. Nishimura (2000)
A Role for the Integrin αvβ8 in the Negative Regulation of Epithelial Cell GrowthCancer Research, 60
A. Keppler, Norbert Gretz, R. Schmidt, Kloetzer Hm, Hermann-Josef GroÈne, B. Lelongt, M. Meyer, M. Sadick, Johannes Pill (2007)
Plasma creatinine determination in mice and rats: an enzymatic method compares favorably with a high-performance liquid chromatography assay.Kidney international, 71 1
S. Segerer, Florian Heller, M. Lindenmeyer, H. Schmid, C. Cohen, Dan Draganovici, J. Mandelbaum, P. Nelson, H. Gröne, E. Gröne, A. Figel, E. Nössner, Detlef Schlöndorff, Detlef Schlöndorff (2008)
Compartment specific expression of dendritic cell markers in human glomerulonephritis.Kidney international, 74 1
Zhuohua Zhang, Alex Morla, K. Vuori, J. Bauer, R. Juliano, E. Ruoslahti (1993)
The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectinThe Journal of Cell Biology, 122
Christian Hugo, S. Shankland, D. Bowen-Pope, W. Couser, Richard Johnson (1997)
Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus.The Journal of clinical investigation, 100 4
J. Schelling, N. Nkemere, Jeffrey Kopp, R. Cleveland (1998)
Fas-dependent fratricidal apoptosis is a mechanism of tubular epithelial cell deletion in chronic renal failure.Laboratory investigation; a journal of technical methods and pathology, 78 7
A. Hartner, I. Marek, Nada Cordasic, C. Haas, Harald Schocklmann, Gudrun Hulsmann-Volkert, Isabel Plasa, W. Rascher, K. Hilgers, K. Amann (2007)
Glomerular Regeneration Is Delayed in Nephritic α8-Integrin-Deficient Mice: Contribution of α8-Integrin to the Regulation of Mesangial Cell ApoptosisAmerican Journal of Nephrology, 28
G. Jarad, Bingcheng Wang, Shenaz Khan, Jay DeVore, H. Miao, Karen Wu, S. Nishimura, B. Wible, M. Konieczkowski, J. Sedor, J. Schelling (2002)
Fas Activation Induces Renal Tubular Epithelial Cell β8 Integrin Expression and Function in the Absence of Apoptosis*The Journal of Biological Chemistry, 277
N. Akis, M. Madaio (2004)
Isolation, culture, and characterization of endothelial cells from mouse glomeruli.Kidney international, 65 6
M. Lopez, E. Pentz, T. Nomasa, O. Smithies, R. Gomez (2004)
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened.Developmental cell, 6 5
T. Wada, M. Shimizu, H. Yokoyama, Y. Iwata, Y. Sakai, S. Kaneko, K. Furuichi (2013)
Nodular lesions and mesangiolysis in diabetic nephropathyClinical and Experimental Nephrology, 17
J. Sedor (1994)
Cytokines, kidney disease, and therapy: a molecular characterization provides insights into mechanism.The Journal of laboratory and clinical medicine, 124 4
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Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened . Dev Cell 6 : 719 – 728 , 2004 . OpenUrl CrossRef Medline Web of Science 41. ↵ Soriano P . Abnormal kidney development and hematological disorders in PDGFβ-receptor mutant mice . Genes Dev 8 : 1888 – 1896 , 1994 . OpenUrl Abstract / FREE Full Text 42. ↵ Srichai MB , Konieczkowski M , Padiyar A , Konieczkowski DJ , Mukherjee A , Hayden PS , Kamat S , El Meanawy MA , Khan S , Mundel P , Lee SB , Bruggeman LA , Schelling JR , Sedor JR . A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus . J Biol Chem 279 : 14398 – 14408 , 2004 . OpenUrl Abstract / FREE Full Text 43. ↵ Stahl RA , Thaiss F , Wenzel U , Helmchen U . Morphologic and functional consequences of immune-mediated mesangiolysis: development of chronic glomerular sclerosis . J Am Soc Nephrol 2 : S144 – S148 , 1992 . OpenUrl Abstract 44. ↵ Travis MA , Reizis B , Melton AC , Masteller E , Tang Q , Proctor JM , Wang Y , Bernstein X , Huang X , Reichardt LF , Bluestone JA , Sheppard D . Loss of integrin α v β 8 on dendritic cells causes autoimmunity and colitis in mice . Nature 449 : 361 – 365 , 2007 . OpenUrl CrossRef Medline Web of Science 45. ↵ Venstrom K , Reichardt L . β 8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin . Mol Biol Cell 6 : 419 – 431 , 1995 . OpenUrl Abstract / FREE Full Text 46. ↵ Vooijs M , Jonkers J , Berns A . A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent . EMBO Rep 2 : 292 – 297 , 2001 . OpenUrl Abstract / FREE Full Text 47. ↵ Wada T , Shimizu M , Yokoyama H , Iwata Y , Sakai Y , Kaneko S , Furuichi K . Nodular lesions and mesangiolysis in diabetic nephropathy . Clin Exp Nephrol 17 : 3 – 9 , 2013 . OpenUrl CrossRef Medline 48. ↵ Weis B , Schmidt J , Lyko F , Linhart HG . Analysis of conditional gene deletion using probe based real-time PCR . BMC Biotechnol 10 : 75 , 2010 . OpenUrl CrossRef Medline 49. ↵ Zhang Z , Morla AO , Vuori K , Bauer JS , Juliano RL , Ruoslahti E . The α v β 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin . J Cell Biol 122 : 235 – 242 , 1993 . OpenUrl Abstract / FREE Full Text 50. ↵ Zhu JW , Motejlek K , Wang DN , Zang KL , Schmidt A , Reichardt LF . β 8 integrins are required for vascular morphogenesis in mouse embryos . Development 129 : 2891 – 2903 , 2002 . OpenUrl Medline Web of Science Previous Next Back to top About the Cover About the Cover Cover image Image 1: Xin Zhang, Zi-Lun Li, John R Woollard, Alfonso Eirin, Behzad Ebrahimi, John A Crane, Xiang- Yang Zhu, Aditya Pawar, James D Krier, Kyra L. Jordan, Hui Tang, Stephen C. Textor, Amir Lerman, and Lilach O. Lerman. 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Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords cell migration extracellular matrix glomerular endothelial cell glomerular injury Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Renal Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair Message Subject (Your Name) has sent you a message from Renal Physiology Message Body (Your Name) thought you would like to see the Renal Physiology web site. Your Personal Message Print Citation Tools Mesangial cell α v β 8 -integrin regulates glomerular capillary integrity and repair Sujata Lakhe-Reddy , Vincent Li , Thomas D. Arnold , Shenaz Khan , Jeffrey R. Schelling American Journal of Physiology - Renal Physiology Jun 2014, 306 (12) F1400-F1409; DOI: 10.1152/ajprenal.00624.2013 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share Mesangial cell α v β 8 -integrin regulates glomerular capillary integrity and repair Mesangial cell α v β 8 -integrin regulates glomerular capillary integrity and repair Sujata Lakhe-Reddy , Vincent Li , Thomas D. Arnold , Shenaz Khan , Jeffrey R. Schelling American Journal of Physiology - Renal Physiology Jun 2014, 306 (12) F1400-F1409; DOI: 10.1152/ajprenal.00624.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria Show more Articles Related Articles No related articles found. 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AJP - Renal Physiology – The American Physiological Society
Published: Jun 15, 2014
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