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Mechanisms of sodium pump regulation

Abstract The Na + -K + -ATPase, or sodium pump, is the membrane-bound enzyme that maintains the Na + and K + gradients across the plasma membrane of animal cells. Because of its importance in many basic and specialized cellular functions, this enzyme must be able to adapt to changing cellular and physiological stimuli. This review presents an overview of the many mechanisms in place to regulate sodium pump activity in a tissue-specific manner. These mechanisms include regulation by substrates, membrane-associated components such as cytoskeletal elements and the γ-subunit, and circulating endogenous inhibitors as well as a variety of hormones, including corticosteroids, peptide hormones, and catecholamines. In addition, the review considers the effects of a range of specific intracellular signaling pathways involved in the regulation of pump activity and subcellular distribution, with particular consideration given to the effects of protein kinases and phosphatases. γ-subunit dopamine norepinephrine aldosterone protein kinase A protein kinase C Footnotes The original work from the authors' laboratories was supported by Medical Research Council of Canada Grant MT-3876, Quebec Heart and Stroke Foundation Grant 209924, and a predoctoral fellowship to A. G. Therien from the Fonds pour la Formation de Chercheurs et d'Aideà la Recherche. Present address of A. G. Therien: Hospital for Sick Children, Division of Structural Biology and Biochemistry, Toronto, Ontario, Canada, M9A 4M6. Address for reprint requests and other correspondence: R. Blostein, Montreal General Hospital, 1650 Cedar Ave., Rm. L11-132, Montreal, Quebec, Canada H3G 1A4 (E-mail: mirb@musica.mcgill.ca ). Copyright © 2000 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

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