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Vol 66, No. 1, Janumy WILLIAM J. BETTGER AND WALLACE L. McKEEHAN Department of Nutrition, Collegeof Biological Science, UniversitZ/ of Guelph, Guelph, Ontario, Canada;and W. Alton JonesCell S&me Center, Lake Placid, New York Introduction .......................................................... Definitions ............................................................ A. Assays for nutritional requirements of isolated cells ................. B. Assays for expression of differentiated function ...................... III. Principles of Cellular Nutrition ........................................ IV. Nutritional Requirements for Cell Survival, Multiplication, and Expression of Differentiated Function .............................. A. Nutrient requirements ............................................. B. Nutrition and cell cycle ............................................. C. Effects of cell density .............................................. D. Interactions among multiple cell types in mixed populations .......... E. Effects of malnutrition ............................................. F. Effects of aging .................................................... V. Mechanisms of Nutrient Metabolism ................................... A. Uptake ............................................................ B. Storage ............................................................ C. Excretion .......................................................... VI. Interactions of Hormones, Growth Factors, and Nutrients ............... A. Nutrients as informational molecules ............................... B. Control of cellular nutritional requirements by hormones and growth factors ................................................. C. Effects of hormones and growth factors on nutrient metabolism ...... ............. D. Effects of nutrient status on autocrine factor production VII. Conclusion ............................................................ I. INTRODUCTION I. II. 1 i 3 Recent technological advances in molecular and cellular biology have drawn the interests of scientists from many
Physiological Reviews – The American Physiological Society
Published: Jan 1, 1986
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