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SOCIETY NUMBER 3 THE AMERICAN _~- 31 PHYSIOLOGICAL JULY I951 Mechanism From VER the Department of Action of Physiology, of the Thyroid State University of Iowa, Hormone Iowa City, Iowa S. B. BARKER SINCE SOME OF THE EARLY clinical observations were made correlating thyroid function with the syndromes of myxedema and thyrotoxicosis, it has been appreciated that the secretion of this gland produced profound effects on many body functions. I lists many of these, studied by means of either spontaneousor experimentally induced changesin thyroid physiology. General aspects are well covered in more comprehensive treatments, such as those of Salter (223)) Williams (278) and by authors in recent Amual Reviews of Physiology. The extreme variety of effects is generally interpreted as indicating a single primary action of the thyroid hormone, probably on energy metabolism, with all of the others representing a secondary dependenceupon integrity of energy pathways. In contradistinction to this is the thesis advanced by some biologists that the thyroid has a specific developmental function independent of any effect on energy transformations (81). Cited to support this view is such evidence as a lack of increase in metabolic e during some stages of amphibian metamorphosis, although the thyroid
Physiological Reviews – The American Physiological Society
Published: Jul 1, 1951
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