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S. J. C. S. CHEW, L. CAMPBELL, Department of Physiology, Emory University, S.J.,C.S.CHEW, L. CAMPBELL,AND E. HOPKS. Mechanism of action of isolated . Am. J. Physiol. 240 (Gastrotest. Liver Physiol. 3): G232-G238, 1981.-Isolated were used to study the mechanism of acid secretory hibition by thiocyanate (). It was found that does not act as a competitive antagonist of histame nor does prevent the crease ceIIuIa.r CAMP associated with histame stimuIation. modifies but does not prevent the expansion of parietal cell canahcuh, dicatg that this characteristic morphological transition does not require the actual formation of hydrochloric acid. Low doses (<5 mM) of were found to hibit amopyre accumulation, an dex of acid formation, but do not hibit either restg or stimulated respiration. Higher doses (>lO mM) of produce significant hibition of stimulated but not restg respiration. These results dicate that has two actions, i.e., hibition of acid formation that requires low doses and hibition of oxidative metabohsm that requires higher doses. cubation of high-K+ (108 mM) medium leads to formation of an acid gradient the absence of other secretagogues. The gradient was found to be transient, and its formation does not require oxidative metabolism, dicatg that contued proton pumpg
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Mar 1, 1981
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