Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Mechanism of action of SCN in isolated gastric glands

Mechanism of action of SCN in isolated gastric glands S. J. C. S. CHEW, L. CAMPBELL, Department of Physiology, Emory University, S.J.,C.S.CHEW, L. CAMPBELL,AND E. HOPKS. Mechanism of action of isolated . Am. J. Physiol. 240 (Gastrotest. Liver Physiol. 3): G232-G238, 1981.-Isolated were used to study the mechanism of acid secretory hibition by thiocyanate (). It was found that does not act as a competitive antagonist of histame nor does prevent the crease ceIIuIa.r CAMP associated with histame stimuIation. modifies but does not prevent the expansion of parietal cell canahcuh, dicatg that this characteristic morphological transition does not require the actual formation of hydrochloric acid. Low doses (<5 mM) of were found to hibit amopyre accumulation, an dex of acid formation, but do not hibit either restg or stimulated respiration. Higher doses (>lO mM) of produce significant hibition of stimulated but not restg respiration. These results dicate that has two actions, i.e., hibition of acid formation that requires low doses and hibition of oxidative metabohsm that requires higher doses. cubation of high-K+ (108 mM) medium leads to formation of an acid gradient the absence of other secretagogues. The gradient was found to be transient, and its formation does not require oxidative metabolism, dicatg that contued proton pumpg http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Loading next page...
 
/lp/the-american-physiological-society/mechanism-of-action-of-scn-in-isolated-gastric-glands-oglupdxPI8

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 1981 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
See Article on Publisher Site

Abstract

S. J. C. S. CHEW, L. CAMPBELL, Department of Physiology, Emory University, S.J.,C.S.CHEW, L. CAMPBELL,AND E. HOPKS. Mechanism of action of isolated . Am. J. Physiol. 240 (Gastrotest. Liver Physiol. 3): G232-G238, 1981.-Isolated were used to study the mechanism of acid secretory hibition by thiocyanate (). It was found that does not act as a competitive antagonist of histame nor does prevent the crease ceIIuIa.r CAMP associated with histame stimuIation. modifies but does not prevent the expansion of parietal cell canahcuh, dicatg that this characteristic morphological transition does not require the actual formation of hydrochloric acid. Low doses (<5 mM) of were found to hibit amopyre accumulation, an dex of acid formation, but do not hibit either restg or stimulated respiration. Higher doses (>lO mM) of produce significant hibition of stimulated but not restg respiration. These results dicate that has two actions, i.e., hibition of acid formation that requires low doses and hibition of oxidative metabohsm that requires higher doses. cubation of high-K+ (108 mM) medium leads to formation of an acid gradient the absence of other secretagogues. The gradient was found to be transient, and its formation does not require oxidative metabolism, dicatg that contued proton pumpg

Journal

AJP - Gastrointestinal and Liver PhysiologyThe American Physiological Society

Published: Mar 1, 1981

There are no references for this article.