We investigated whether markers of inflammation, including a cytokine (IL-6), acute-phase reactants C-reactive protein (CRP) and fibrinogen, and white blood cell (WBC) count are associated with maximal O 2 consumption ( O 2 max ) in men without coronary heart disease (CHD). In asymptomatic men ( n = 172, 51 ± 9.3 yr old), O 2 max was measured during a symptom-limited graded treadmill exercise test. Physical activity level was assessed by a standardized questionnaire. IL-6 and CRP were measured by immunoassays, fibrinogen by the Clauss method, and WBC count with a Coulter counter. IL-6 and CRP were logarithmically transformed to reduce skewness. Multivariable regression was used to assess whether markers of inflammation were associated with O 2 max after adjustment for age, body mass index, CHD risk factors, and lifestyle variables (physical activity level, percent body fat, and alcohol intake). O 2 max was 34.5 ml·kg –1 ·min –1 (SD 6.1). Log IL-6 ( r = –0.38, P < 0.001), log CRP ( r = –0.40, P < 0.001), fibrinogen ( r = –0.42, P < 0.001), and WBC count ( r = –0.22, P = 0.004) were each correlated with O 2 max . In separate multivariable linear regression models that adjusted for age, body mass index, CHD risk factors, and lifestyle variables, log IL-6 -coeff = –1.66 ± 0.63 (SE), P = 0.010, log CRP -coeff = –0.99 ± 0.33 (SE), P = 0.003, fibrinogen -coeff = –1.51 ± 0.44 (SE), P = 0.001, and WBC count -coeff = –0.52 ± 0.30 (SE), P = 0.088 were each inversely associated with O 2 max . In conclusion, higher circulating levels of IL-6, CRP, and fibrinogen are independently associated with lower O 2 max in asymptomatic men. fitness; interleukin-6; C-reactive protein; fibrinogen Address for reprint requests and other correspondence: I. J. Kullo, Div. of Cardiovascular Diseases, Mayo Clinic, 200 First St. SW, Rochester, MN 55905 (e-mail: email@example.com )
Journal of Applied Physiology – The American Physiological Society
Published: Apr 1, 2007
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