Markers of inflammation are inversely associated with VO2 max in asymptomatic men

Markers of inflammation are inversely associated with VO2 max in asymptomatic men We investigated whether markers of inflammation, including a cytokine (IL-6), acute-phase reactants C-reactive protein (CRP) and fibrinogen, and white blood cell (WBC) count are associated with maximal O 2 consumption ( O 2 max ) in men without coronary heart disease (CHD). In asymptomatic men ( n = 172, 51 ± 9.3 yr old), O 2 max was measured during a symptom-limited graded treadmill exercise test. Physical activity level was assessed by a standardized questionnaire. IL-6 and CRP were measured by immunoassays, fibrinogen by the Clauss method, and WBC count with a Coulter counter. IL-6 and CRP were logarithmically transformed to reduce skewness. Multivariable regression was used to assess whether markers of inflammation were associated with O 2 max after adjustment for age, body mass index, CHD risk factors, and lifestyle variables (physical activity level, percent body fat, and alcohol intake). O 2 max was 34.5 ml·kg –1 ·min –1 (SD 6.1). Log IL-6 ( r = –0.38, P < 0.001), log CRP ( r = –0.40, P < 0.001), fibrinogen ( r = –0.42, P < 0.001), and WBC count ( r = –0.22, P = 0.004) were each correlated with O 2 max . In separate multivariable linear regression models that adjusted for age, body mass index, CHD risk factors, and lifestyle variables, log IL-6 -coeff = –1.66 ± 0.63 (SE), P = 0.010, log CRP -coeff = –0.99 ± 0.33 (SE), P = 0.003, fibrinogen -coeff = –1.51 ± 0.44 (SE), P = 0.001, and WBC count -coeff = –0.52 ± 0.30 (SE), P = 0.088 were each inversely associated with O 2 max . In conclusion, higher circulating levels of IL-6, CRP, and fibrinogen are independently associated with lower O 2 max in asymptomatic men. fitness; interleukin-6; C-reactive protein; fibrinogen Address for reprint requests and other correspondence: I. J. Kullo, Div. of Cardiovascular Diseases, Mayo Clinic, 200 First St. SW, Rochester, MN 55905 (e-mail: kullo.iftikhar@mayo.edu ) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Markers of inflammation are inversely associated with VO2 max in asymptomatic men

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Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
D.O.I.
10.1152/japplphysiol.01028.2006
Publisher site
See Article on Publisher Site

Abstract

We investigated whether markers of inflammation, including a cytokine (IL-6), acute-phase reactants C-reactive protein (CRP) and fibrinogen, and white blood cell (WBC) count are associated with maximal O 2 consumption ( O 2 max ) in men without coronary heart disease (CHD). In asymptomatic men ( n = 172, 51 ± 9.3 yr old), O 2 max was measured during a symptom-limited graded treadmill exercise test. Physical activity level was assessed by a standardized questionnaire. IL-6 and CRP were measured by immunoassays, fibrinogen by the Clauss method, and WBC count with a Coulter counter. IL-6 and CRP were logarithmically transformed to reduce skewness. Multivariable regression was used to assess whether markers of inflammation were associated with O 2 max after adjustment for age, body mass index, CHD risk factors, and lifestyle variables (physical activity level, percent body fat, and alcohol intake). O 2 max was 34.5 ml·kg –1 ·min –1 (SD 6.1). Log IL-6 ( r = –0.38, P < 0.001), log CRP ( r = –0.40, P < 0.001), fibrinogen ( r = –0.42, P < 0.001), and WBC count ( r = –0.22, P = 0.004) were each correlated with O 2 max . In separate multivariable linear regression models that adjusted for age, body mass index, CHD risk factors, and lifestyle variables, log IL-6 -coeff = –1.66 ± 0.63 (SE), P = 0.010, log CRP -coeff = –0.99 ± 0.33 (SE), P = 0.003, fibrinogen -coeff = –1.51 ± 0.44 (SE), P = 0.001, and WBC count -coeff = –0.52 ± 0.30 (SE), P = 0.088 were each inversely associated with O 2 max . In conclusion, higher circulating levels of IL-6, CRP, and fibrinogen are independently associated with lower O 2 max in asymptomatic men. fitness; interleukin-6; C-reactive protein; fibrinogen Address for reprint requests and other correspondence: I. J. Kullo, Div. of Cardiovascular Diseases, Mayo Clinic, 200 First St. SW, Rochester, MN 55905 (e-mail: kullo.iftikhar@mayo.edu )

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Apr 1, 2007

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