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Our objective was to test the hypothesis that endothelial selectins, P and E selectins, are necessary for leukocyte migration after muscle injury from unloading/reloading. Mice hindlimbs were suspended for 10 days followed by reloading periods of 6 or 24 h after which the soleus muscle was dissected. Light microscopic observations showed that macrophages, but not neutrophils, were able to invade soleus muscles in mice deficient in P/E selectins (P/E -/- ) during reloading periods. The recruitment efficiency of neutrophils after 6 and 24 h of reloading was minimal in P/E -/- mice relative to unloaded animals. The recruitment of macrophages in the soleus muscle was preserved in P/E -/- mice. The concentration of macrophages increased by 8.1-fold compared with unloaded muscles in double-mutant mice after 24 h of reloading. The accumulation of macrophages in reloaded muscles did not lead to fiber necrosis. Together, these findings indicate that macrophages can invade skeletal muscle through cellular mechanisms that do not involve P/E selectins during skeletal muscle reloading. muscle inflammation; mechanical stress; hindlimb suspension Address for reprint requests and other correspondence: J. Frenette, CHUL Research Center, Rm. 9500, 2705 Blvd. Laurier, Ste-Foy, Quebec, G1V 4G2 Canada (E-mail: jerome.frenette@crchul.ulaval.ca ).
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Oct 1, 2003
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