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Electrostimulatory forms of therapy can reduce angina that arises from activation of cardiac nociceptive afferent fibers during transient ischemia. This study sought to determine the effects of electrical stimulation of left thoracic vagal afferents (C 8 –T 1 level) on the release of putative nociceptive substance P (SP) and analgesic dynorphin (Dyn) peptides in the dorsal horn at the T 4 spinal level during coronary artery occlusion in urethane-anesthetized Sprague-Dawley rats. Release of Dyn and SP was measured by using antibody-coated microprobes. While Dyn and SP had a basal release, occlusion of the left anterior descending coronary artery only affected SP release, causing an increase from lamina I-VII. Left vagal stimulation increased Dyn release, inhibited basal SP release, and blunted the coronary artery occlusion-induced release of SP. Dyn release reflected activation of descending pathways in the thoracic spinal cord, because vagal afferent stimulation still increased the release of Dyn after bilateral dorsal rhizotomy of T 2 –T 5 . These results indicate that electrostimulatory therapy, using vagal afferent excitation, may induce analgesia, in part, via inhibition of the release of SP in the spinal cord, possibly through a Dyn-mediated neuronal interaction. antibody-coated microprobes; angina; cardiac nervous system; analgesic peptides; nociceptive peptides Address for reprint requests and other correspondence: C. Williams, Dept. of Physiology, Quillen College of Medicine, East Tennessee State Univ., P.O. Box 70576, Stanton-Gerber Hall B-137, Johnson City, TN 37614–1708 (E-mail: williams@mail.etsu.edu )
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Dec 1, 2004
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