Ischemic preconditioning stimulates anaerobic glycolysis in the isolated rabbit heart

Ischemic preconditioning stimulates anaerobic glycolysis in the isolated rabbit heart Janier, Marc F., Jean-Louis J. Vanoverschelde, and Steven R. Bergmann. Ischemic preconditioning stimulates anaerobic in the isolated rabbit heart. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1353-H1360, 1994.Preconditioning decreases ischemic injury, preserves tissue ATP content, and enhances the salutary effects of reperfusion. To evaluate whether preserved ATP is related to reduced utilization or increased production, 28 paced isolated rabbit hearts, perfused at constant flow, were subjected to 3 min of transient no-flow ischemia followed 12 min later by 1 h of low-flow ischemia and 45 min of reperfusion. Results were compared with those from 34 control hearts subjected to ischemia and reperfusion without preconditioning. Preconditioning delayed the onset of ischemic contracture and decreased its amplitude. At the end of ischemia, tissue ATP content was higher in hearts subjected to preconditioning (9.8 t 3.3 vs. 4.5 t 1.1 pmol/g dry wt; P < O.Ol), accounted for by increased anaerobic ATP production using exogenous glucose. Preconditioning decreased ischemic damage (creatine kinase release 373 t 199 vs. 587 t 291 U/g dry wt; P < 0.05) and resulted in better functional recovery with reperfusion (74 t 11% of baseline developed pressure vs. 60 2 23%; P < 0.05). Thus preconditioning http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Ischemic preconditioning stimulates anaerobic glycolysis in the isolated rabbit heart

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Publisher
The American Physiological Society
Copyright
Copyright © 1994 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

Janier, Marc F., Jean-Louis J. Vanoverschelde, and Steven R. Bergmann. Ischemic preconditioning stimulates anaerobic in the isolated rabbit heart. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1353-H1360, 1994.Preconditioning decreases ischemic injury, preserves tissue ATP content, and enhances the salutary effects of reperfusion. To evaluate whether preserved ATP is related to reduced utilization or increased production, 28 paced isolated rabbit hearts, perfused at constant flow, were subjected to 3 min of transient no-flow ischemia followed 12 min later by 1 h of low-flow ischemia and 45 min of reperfusion. Results were compared with those from 34 control hearts subjected to ischemia and reperfusion without preconditioning. Preconditioning delayed the onset of ischemic contracture and decreased its amplitude. At the end of ischemia, tissue ATP content was higher in hearts subjected to preconditioning (9.8 t 3.3 vs. 4.5 t 1.1 pmol/g dry wt; P < O.Ol), accounted for by increased anaerobic ATP production using exogenous glucose. Preconditioning decreased ischemic damage (creatine kinase release 373 t 199 vs. 587 t 291 U/g dry wt; P < 0.05) and resulted in better functional recovery with reperfusion (74 t 11% of baseline developed pressure vs. 60 2 23%; P < 0.05). Thus preconditioning

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Oct 1, 1994

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