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R. Glowik, J. Golowasch, R. Keller, E. Marder (1997)
D-glucose-sensitive neurosecretory cells of the crab Cancer borealis and negative feedback regulation of blood glucose level.The Journal of experimental biology, 200 Pt 10
J. Luther, A. Robie, John Yarotsky, Christopher Reina, E. Marder, J. Golowasch (2003)
Episodic bouts of activity accompany recovery of rhythmic output by a neuromodulator- and activity-deprived adult neural network.Journal of neurophysiology, 90 4
Wei Zhang, D. Linden (2003)
The other side of the engram: experience-driven changes in neuronal intrinsic excitabilityNature Reviews Neuroscience, 4
G. Turrigiano, G. Lemasson, E. Marder (1995)
Selective regulation of current densities underlies spontaneous changes in the activity of cultured neurons, 15
A. Ivanov, R. Calabrese (2006)
Spike-mediated and graded inhibitory synaptic transmission between leech interneurons: evidence for shared release sites.Journal of neurophysiology, 96 1
P. Koninck, H. Schulman (1998)
Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations.Science, 279 5348
J. Chung, J. Huguenard, D. Prince (1993)
Transient enhancement of low-threshold calcium current in thalamic relay neurons after corticectomy.Journal of neurophysiology, 70 1
Xiao Yu, Kailai Duan, Chun-feng Shang, Hanping Yu, Zhuan Zhou (2004)
Calcium influx through hyperpolarization-activated cation channels (I(h) channels) contributes to activity-evoked neuronal secretion.Proceedings of the National Academy of Sciences of the United States of America, 101 4
Lia Cesana, J. Mapelli, E. D’Angelo (2006)
Ionic mechanisms of autorhythmic firing in rat cerebellar Golgi cellsThe Journal of Physiology, 574
G. Davis, Ilya Bezprozvanny (2001)
Maintaining the stability of neural function: a homeostatic hypothesis.Annual review of physiology, 63
J. Golowasch, M. Casey, Larry Abbott, E. Marder (1999)
Network Stability from Activity-Dependent Regulation of Neuronal ConductancesNeural Computation, 11
G. Turrigiano, E. Marder (1993)
Modulation of identified stomatogastric ganglion neurons in primary cell culture.Journal of neurophysiology, 69 6
J. Klein, E. Tendi, S. Dib-Hajj, R. Fields, S. Waxman (2003)
Patterned electrical activity modulates sodium channel expression in sensory neuronsJournal of Neuroscience Research, 74
A. Swensen, E. Marder (2000)
Multiple Peptides Converge to Activate the Same Voltage-Dependent Current in a Central Pattern-Generating CircuitThe Journal of Neuroscience, 20
A. Ivanov, R. Calabrese (2006)
Graded inhibitory synaptic transmission between leech interneurons: assessing the roles of two kinetically distinct low-threshold Ca currents.Journal of neurophysiology, 96 1
C. Mee, Edward Pym, K. Moffat, R. Baines (2004)
Regulation of Neuronal Excitability through Pumilio-Dependent Control of a Sodium Channel GeneThe Journal of Neuroscience, 24
J. Sáez, J. Connor, D. Spray, M. Bennett (1989)
Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.Proceedings of the National Academy of Sciences of the United States of America, 86 8
A. Parekh (2006)
Cell biology: Cracking the calcium entry codeNature, 441
M. Thoby-Brisson, J. Simmers (1998)
Neuromodulatory Inputs Maintain Expression of a Lobster Motor Pattern-Generating Network in a Modulation-Dependent State: Evidence from Long-Term Decentralization In VitroThe Journal of Neuroscience, 18
C. Darlington, M. Dutia, Paul Smith (2002)
The contribution of the intrinsic excitability of vestibular nucleus neurons to recovery from vestibular damageEuropean Journal of Neuroscience, 15
G. Maccaferri, C. McBain (1996)
The hyperpolarization‐activated current (Ih) and its contribution to pacemaker activity in rat CA1 hippocampal stratum oriens‐alveus interneurones.The Journal of Physiology, 497
E. DeLorme, C. Rabe, R. Mcgee (1988)
Regulation of the number of functional voltage-sensitive Ca++ channels on PC12 cells by chronic changes in membrane potential.The Journal of pharmacology and experimental therapeutics, 244 3
H. Schulman, K. Heist, M. Srinivasan (1995)
Decoding Ca2+ signals to the nucleus by multifunctional CaM kinase.Progress in brain research, 105
Robert Cudmore, G. Turrigiano (2004)
Long-term potentiation of intrinsic excitability in LV visual cortical neurons.Journal of neurophysiology, 92 1
M. Li, M. Jia, R. Fields, P. Nelson (1996)
Modulation of calcium currents by electrical activity.Journal of neurophysiology, 76 4
Y. Panchin, Y. Arshavsky, A. Selverston, T. Cleland (1993)
Lobster stomatogastric neurons in primary culture. I. Basic characteristics.Journal of neurophysiology, 69 6
Micaela Galante, D. Avossa, M. Rosato-Siri, L. Ballerini (2001)
Homeostatic plasticity induced by chronic block of AMPA/kainate receptors modulates the generation of rhythmic bursting in rat spinal cord organotypic culturesEuropean Journal of Neuroscience, 14
N. Spitzer, P. Kingston, T. Manning, M. Conklin (2002)
Outside and in: development of neuronal excitabilityCurrent Opinion in Neurobiology, 12
A. Selverston, D. Russell, John Miller, D. King (1976)
The stomatogastric nervous system: Structure and function of a small neural networkProgress in Neurobiology, 7
G. Turrigiano, S. Nelson (2004)
Homeostatic plasticity in the developing nervous systemNature Reviews Neuroscience, 5
Niraj Desai, L. Rutherford, G. Turrigiano (1999)
Plasticity in the intrinsic excitability of cortical pyramidal neuronsNature Neuroscience, 2
P. Smith, F. Ashcroft, Ci~re Fewtrell, F. Ashcrofi (1993)
Permeation and gating properties of the L-type calcium channel in mouse pancreatic beta cellsThe Journal of General Physiology, 101
G. Turrigiano, L. Abbott, E. Marder (1994)
Activity-dependent changes in the intrinsic properties of cultured neurons.Science, 264 5161
K. Graubard, D. Hartline (1991)
Voltage clamp analysis of intact stomatogastric neuronsBrain Research, 557
J. Golowasch, E. Marder (1992)
Ionic currents of the lateral pyloric neuron of the stomatogastric ganglion of the crab.Journal of neurophysiology, 67 2
M. Nusbaum, M. Beenhakker (2002)
A small-systems approach to motor pattern generationNature, 417
Ling-Gang Wu, R. Westenbroek, J. Borst, W. Catterall, B. Sakmann (1999)
Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type SynapsesThe Journal of Neuroscience, 19
Hailing Su, D. Sochivko, A. Becker, Jing Chen, Yanwen Jiang, Y. Yaari, H. Beck (2002)
Upregulation of a T-Type Ca2+ Channel Causes a Long-Lasting Modification of Neuronal Firing Mode after Status EpilepticusThe Journal of Neuroscience, 22
A. Mizrahi, P. Dickinson, P. Kloppenburg, V. Fénelon, D. Baro, R. Harris-Warrick, P. Meyrand, J. Simmers (2001)
Long-Term Maintenance of Channel Distribution in a Central Pattern Generator Neuron by Neuromodulatory Inputs Revealed by Decentralization in Organ CultureThe Journal of Neuroscience, 21
P. Linsdell, W. Moody (1994)
Na+ channel mis‐expression accelerates K+ channel development in embryonic Xenopus laevis skeletal muscle.The Journal of Physiology, 480
Gaël Daoudal, D. Debanne (2003)
Long-term plasticity of intrinsic excitability: learning rules and mechanisms.Learning & memory, 10 6
M. Thoby-Brisson, J. Simmers (2002)
Long-term neuromodulatory regulation of a motor pattern-generating network: maintenance of synaptic efficacy and oscillatory properties.Journal of neurophysiology, 88 6
Y. Gorbunova, N. Spitzer (2002)
Dynamic interactions of cyclic AMP transients and spontaneous Ca2+ spikesNature, 418
J. Golowasch, L. Abbott, E. Marder (1999)
Activity-Dependent Regulation of Potassium Currents in an Identified Neuron of the Stomatogastric Ganglion of the Crab Cancer borealisThe Journal of Neuroscience, 19
R. Fields (1994)
Regulation of neurite outgrowth and immediate early gene expression by patterned electrical stimulation.Progress in brain research, 103
J. Franklin, DJ Fickbohm, A. Willard (1992)
Long-term regulation of neuronal calcium currents by prolonged changes of membrane potential, 12
R. Dolmetsch, Keli Xu, R. Lewis (1998)
Calcium oscillations increase the efficiency and specificity of gene expressionNature, 392
M. Thoby-Brisson, J. Simmers (2000)
Transition to endogenous bursting after long-term decentralization requires De novo transcription in a critical time window.Journal of neurophysiology, 84 1
A. West, Eric Griffith, M. Greenberg (2002)
Regulation of transcription factors by neuronal activityNature Reviews Neuroscience, 3
(1994)
J Physiol
L. Hurley, K. Graubard (1998)
Pharmacologically and functionally distinct calcium currents of stomatogastric neurons.Journal of neurophysiology, 79 4
(2001)
Tonic, low-threshold calcium influx regulates cytoplasmic calcium levels in stomatogastric motoneurons
S. Hong, GA Lnenicka (1995)
Activity-dependent reduction in voltage-dependent calcium current in a crayfish motoneuron, 15
Y. Feuvre, V. Fénelon, P. Meyrand (1999)
Central inputs mask multiple adult neural networks within a single embryonic networkNature, 402
H. Bito, K. Deisseroth, R. Tsien (1997)
Ca2+-dependent regulation in neuronal gene expressionCurrent Opinion in Neurobiology, 7
I. Hobai, A. Levi (1999)
Coming full circle: membrane potential, sarcolemmal calcium influx and excitation-contraction coupling in heart muscle.Cardiovascular research, 44 3
D. Garcia, A. Cavalié, H. Lux (1994)
Enhancement of voltage-gated Ca2+ currents induced by daily stimulation of hippocampal neurons with glutamate, 14
T. Soderling, Bill Chang, D. Brickey (2001)
Cellular Signaling through Multifunctional Ca2+/Calmodulin-dependent Protein Kinase II*The Journal of Biological Chemistry, 276
A. Swensen, E. Marder (2001)
Modulators with Convergent Cellular Actions Elicit Distinct Circuit OutputsThe Journal of Neuroscience, 21
Eve Marder, L. Abbott, G. Turrigiano, Zheng Liu, J. Golowasch (1996)
Memory from the dynamics of intrinsic membrane currents.Proceedings of the National Academy of Sciences of the United States of America, 93 24
M. Taussig (1991)
The Nervous System
D. Noble, J. Denyer, H. Brown, D. DiFrancesco (1992)
Reciprocal role of the inward currents ib, Na and if in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cellsProceedings of the Royal Society of London. Series B: Biological Sciences, 250
Zheng Liu, J. Golowasch, E. Marder, L. Abbott (1998)
A Model Neuron with Activity-Dependent Conductances Regulated by Multiple Calcium SensorsThe Journal of Neuroscience, 18
V. Kilman, E. Marder (1996)
Ultrastructure of the stomatogastric ganglion neuropil of the crab, Cancer borealis.The Journal of comparative neurology, 374 3
D. McCormick, T. Bal (1997)
Sleep and arousal: thalamocortical mechanisms.Annual review of neuroscience, 20
T. Bal, F. Nagy, M. Moulins (1988)
The pyloric central pattern generator in Crustacea: a set of conditional neuronal oscillatorsJournal of Comparative Physiology A, 163
Andrew Sharp, M. O'Neil, L. Abbott, Eve Marder (1993)
Dynamic clamp: computer-generated conductances in real neurons.Journal of neurophysiology, 69 3
Neurons exhibit long-term excitability changes necessary for maintaining proper cell and network activity in response to various inputs and perturbations. For instance, the adult crustacean pyloric network can spontaneously recover rhythmic activity after complete shutdown resulting from permanent removal of neuromodulatory inputs. Dissociated lobster stomatogastric ganglion (STG) neurons have been shown to spontaneously develop oscillatory activity via excitability changes. Rhythmic electrical stimulation can eliminate these oscillatory patterns in some cells. The ionic mechanisms underlying these changes are only partially understood. We used dissociated crab STG neurons to study the ionic mechanisms underlying spontaneous recovery of rhythmic activity and stimulation-induced activity changes. Similar to lobster neurons, rhythmic activity spontaneously develops in crab STG neurons. Rhythmic hyperpolarizing stimulation can eliminate, but more commonly accelerate, the emergence of stable oscillatory activity depending on Ca 2+ influx at hyperpolarized voltages. Our main finding is that upregulation of a Ca 2+ current and downregulation of a high-threshold K + current underlies the spontaneous homeostatic development of oscillatory activity. However, because of a nonlinear dependence on stimulus frequency, hyperpolarization-induced oscillations appear to be inconsistent with a homeostatic regulation of activity. We find no difference in the activity patterns or the underlying ionic currents involved between neurons of the fast pyloric and the slow gastric mill networks during the first 10 days in isolation. Dynamic-clamp experiments confirm that these conductance modifications can explain the observed activity changes. We conclude that spontaneous and stimulation-induced excitability changes in STG neurons can both result in intrinsic oscillatory activity via regulation of the same two conductances. Address for reprint requests and other correspondence: J. Golowasch, Dept. Mathematical Sciences, NJIT, University Heights, Newark, NJ 07102 (E-mail: Jorge.P.Golowasch@njit.edu )
Journal of Neurophysiology – The American Physiological Society
Published: Oct 1, 2006
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