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Ion channels in normal human and cystic fibrosis sweat gland cells

M. E. KROUSE, G. HAGIWARA, J. CHEN, N. J. LEWISTON, AND J. J. WINE Cystic Fibrosis Research Laboratory, Stanford University, and Ross Mosier Laboratory, Children’s Hospital at Stanford, Stanford, California 94305-2130 E., G. HAGIWARA, J. CHEN, N. J. LEWISTON, channels in normal human and cystic fibrosis sweat gland cells. Am. J. Physiol. 257 (Cell Physiol. 26): C129-C140, 1989.-Single-channel patch-clamp techniques were used to study the populat of apical membrane channels in cultured sweat gland secretory cells from normal and cystic fibrosis subjects. Four types of an channels and two types of cat channels were found. At physiological s, an channels had chord conductances of 10, 18, 24, and >200 pS. All had linear current- relats except the 24 pS channel, which showed outward rectificat. Cat channels had chord conductances of 5 and 18 pS, were linear, and were nonselective for a variety of cats. Channel types and proports were equivalent in control, cystic fibrosis, and cystic fibrosis heterozygote cells. Beyond showing that the distribut of channel types remains unchanged in cystic fibrosis cells, the data provide a basis for comparison with cells cultured under different condits, with other cell types, and with native tissues. cell culture; secretory cells; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

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