JAMES L. CAFFREY, ZAIRA MATEO, LESLIE D. NAPIER, JOHN F. GAUGL, AND BARBARA A. BARRON Department of Physiology, University of North Texas Health Fort Worth, Texas 76107 Caffrey, James L., Zaira Mateo, Leslie D. Napier, John F. Gaugl, and Barbara A. Barron. Intrinsic cardiac s inhibit in the dog. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H848-H855, 1995.Met--Arg-Phe () has been identified in acid extracts of canine heart tissue. The effects of synthetic on the control of heart rate were investigated in anesthetized dogs. The arterial infusion of (3 nmol. min. kg-l) inhibited the observed during electrical stimulation of the right vagus nerve by 72%. After the infusion was stopped, the responsiveness to stimulation returned to normal, with a half-time between 2 and 3 min. The inhibition by was reversed by the high-affinity opiate antagonist diprenorphine (100 pg/kg). did not alter the negative chronotropic effect of the direct-acting muscarinic agonist methacholine. This observation suggested that exerted its effect at a site in the efferent tract proximal to nodal muscarinic receptors. Increasing infusions (0.09-3.00 nmolminlo kg-l) produced a graded suppression of , with a half-maximal effect near 0.3 nmol . min- l kg- l. Met- (ME) produced responses
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Feb 1, 1995
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