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vide a vehicle for rapid hydrolysis and due to their smaller molecular size and greater water solubility in comparison to LCT. Although STG retain some characteristics MCT and LCT, they may be an alternative lipid source that could overcome the gastro intolerance related to the sole use MCT or LCT in critically ill patients. By varying the molar ratios the starting oils used in the synthesis STG, specific ratios n-3, n-6, and n-9 fatty acids can be selected for distinct nutritional and medical uses. Metabolic benefits STG have been demonstrated in animal models trauma, burn injury, and endotoxic shock (7, 8, 11, 18, 20, 24, 25, 26). Attenuation the hypermetabolic and protein catabolic response to burn injury was observed in thermally injured rats receiving STG either parenterally or enterally (7,8, 11,18,20,24, 25). Rats receiving the STG containing both mediumchain and long-chain fatty acids showed the greatest gain in body weight, enhanced skeletal muscle, and liver protein synthesis, as well as markedly increased nitrogen retention and serum albumin concentration over comparable groups rats given LCT, MCT, or a physical mixture LCT and MCT (7, 8, 18, 20, 25). Fatty infiltration the liver and reticuloend .othelial system overload were substantially
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Apr 1, 1995
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