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Intestinal digestion, absorption, and transport of structured triglycerides and cholesterol in rats

Intestinal digestion, absorption, and transport of structured triglycerides and cholesterol in rats vide a vehicle for rapid hydrolysis and due to their smaller molecular size and greater water solubility in comparison to LCT. Although STG retain some characteristics MCT and LCT, they may be an alternative lipid source that could overcome the gastro intolerance related to the sole use MCT or LCT in critically ill patients. By varying the molar ratios the starting oils used in the synthesis STG, specific ratios n-3, n-6, and n-9 fatty acids can be selected for distinct nutritional and medical uses. Metabolic benefits STG have been demonstrated in animal models trauma, burn injury, and endotoxic shock (7, 8, 11, 18, 20, 24, 25, 26). Attenuation the hypermetabolic and protein catabolic response to burn injury was observed in thermally injured rats receiving STG either parenterally or enterally (7,8, 11,18,20,24, 25). Rats receiving the STG containing both mediumchain and long-chain fatty acids showed the greatest gain in body weight, enhanced skeletal muscle, and liver protein synthesis, as well as markedly increased nitrogen retention and serum albumin concentration over comparable groups rats given LCT, MCT, or a physical mixture LCT and MCT (7, 8, 18, 20, 25). Fatty infiltration the liver and reticuloend .othelial system overload were substantially http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Intestinal digestion, absorption, and transport of structured triglycerides and cholesterol in rats

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
See Article on Publisher Site

Abstract

vide a vehicle for rapid hydrolysis and due to their smaller molecular size and greater water solubility in comparison to LCT. Although STG retain some characteristics MCT and LCT, they may be an alternative lipid source that could overcome the gastro intolerance related to the sole use MCT or LCT in critically ill patients. By varying the molar ratios the starting oils used in the synthesis STG, specific ratios n-3, n-6, and n-9 fatty acids can be selected for distinct nutritional and medical uses. Metabolic benefits STG have been demonstrated in animal models trauma, burn injury, and endotoxic shock (7, 8, 11, 18, 20, 24, 25, 26). Attenuation the hypermetabolic and protein catabolic response to burn injury was observed in thermally injured rats receiving STG either parenterally or enterally (7,8, 11,18,20,24, 25). Rats receiving the STG containing both mediumchain and long-chain fatty acids showed the greatest gain in body weight, enhanced skeletal muscle, and liver protein synthesis, as well as markedly increased nitrogen retention and serum albumin concentration over comparable groups rats given LCT, MCT, or a physical mixture LCT and MCT (7, 8, 18, 20, 25). Fatty infiltration the liver and reticuloend .othelial system overload were substantially

Journal

AJP - Gastrointestinal and Liver PhysiologyThe American Physiological Society

Published: Apr 1, 1995

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