Green, Richard M., James F. Whiting, Adam B. Rosenbluth, David Beier, John L. Gollan. Interleukin-6 taurocholate uptake sodium-potassiumadenosinetriphosphatase activity. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G1094-GllOO, 1994.-The potential effects of cytokines on hepatocellular transport functions remain undefined. Interleukin-6 () is a cytokine that is produced in sepsis, hepatitis, other inflammatory conditions often associated with cholestasis. Using cultured rat s, we have investigated the effects of on hepatocellular bile salt uptake. Because Na+-K+adenosinetriphosphatase (ATPase) produces the electrochemical gradient that drives sodium-dependent bile salt cotransport, we also examined the effects of on activity. s cultured for 20 h in media containing exhibited a dose-dependent noncompetitive inhibition of [3H]taurocholate uptake, which was maximal at an dose of 100 U/ml. treatment had no effect on sodium-independent taurocholate uptake. Northern blotting of RNA from cultured s revealed that had no effect on steady-state RNA levels of the Na+-taurocholate transporter (Ntcp). s incubated with for 20 h, however, exhibited a 55% decrease in Na+-K+ATPase activity. This effect also was dose dependent, with maximal inhibition occurring at an dose of 100 U/ml. Similar treatment with did not influence Mg2+-ATPase activity. The inhibition of activity induced by provides a putative mechanism for the observed
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Dec 1, 1994
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