Insulin sensitivity and glucose effectiveness: minimal model analysis of regular and insulin-modified FSIGT

Insulin sensitivity and glucose effectiveness: minimal model analysis of regular and... Abstract The minimal model is widely used to evaluate insulin action on glucose disappearance from frequently sampled intravenous glucose tolerance tests (FSIGT). The common protocols are a regular (rFSIGT, single injection of 0.3 g/kg of glucose) and an insulin-modified test (mFSIGT, with an additional insulin administration at 20 min). This study compared the insulin sensitivity index (S I ) and glucose effectiveness (S G ) obtained in the same individual (16 normal subjects) with the two tests. S I was 7.11 ± 0.80 10 −4 ⋅ min −1 ⋅ μU −1 ⋅ ml in rFSIGT and 6.96 ± 0.83 in mFSIGT ( P = 0.656), regression r = 0.92, P < 0.0001; S G was 0.0260 ± 0.0028 min −1 and 0.0357 ± 0.0052, respectively, statistically different ( P = 0.013) but still with a good regression ( r = 0.66, P = 0.0051). S G and insulin amount during the early period correlated ( r = 0.6, P = 0.015 in rFSIGT and r = 0.76, P = 0.0006 in mFSIGT). In summary, both FSIGTs with minimal model analysis provide the same S I , which is a very robust index. S G was different by 28% due probably to the relationship between S G and the amount of circulating insulin. In studies comparing groups, the simpler rFSIGT can still be used with the advantage of accounting for endogenous insulin, thus offering the possibility of direct inferences on the β-cell activity. frequently sampled intravenous glucose tolerance test glucose tolerance minimal model protocols insulin action Footnotes Address for reprint requests: G. Pacini, LADSEB-CNR, Corso Stati Uniti, 4, 35127 Padova, Italy. Romano Nosadini is also affiliated with the Institute of Internal Medicine and with the CNR Centre for Studies on Aging, University of Padova. Maria Sambataro is currently affiliated with the Division of Medicine of the Hospital of Porto Viro (Rovigo). A portion of this work was presented at the 32nd Congress of the European Association for the Study of Diabetes in Vienna, Austria (September 1996) and was published as abstract 600 in Diabetologia 39, Suppl . 1: 158A, 1996. Copyright © 1998 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Insulin sensitivity and glucose effectiveness: minimal model analysis of regular and insulin-modified FSIGT

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Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
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Abstract

Abstract The minimal model is widely used to evaluate insulin action on glucose disappearance from frequently sampled intravenous glucose tolerance tests (FSIGT). The common protocols are a regular (rFSIGT, single injection of 0.3 g/kg of glucose) and an insulin-modified test (mFSIGT, with an additional insulin administration at 20 min). This study compared the insulin sensitivity index (S I ) and glucose effectiveness (S G ) obtained in the same individual (16 normal subjects) with the two tests. S I was 7.11 ± 0.80 10 −4 ⋅ min −1 ⋅ μU −1 ⋅ ml in rFSIGT and 6.96 ± 0.83 in mFSIGT ( P = 0.656), regression r = 0.92, P < 0.0001; S G was 0.0260 ± 0.0028 min −1 and 0.0357 ± 0.0052, respectively, statistically different ( P = 0.013) but still with a good regression ( r = 0.66, P = 0.0051). S G and insulin amount during the early period correlated ( r = 0.6, P = 0.015 in rFSIGT and r = 0.76, P = 0.0006 in mFSIGT). In summary, both FSIGTs with minimal model analysis provide the same S I , which is a very robust index. S G was different by 28% due probably to the relationship between S G and the amount of circulating insulin. In studies comparing groups, the simpler rFSIGT can still be used with the advantage of accounting for endogenous insulin, thus offering the possibility of direct inferences on the β-cell activity. frequently sampled intravenous glucose tolerance test glucose tolerance minimal model protocols insulin action Footnotes Address for reprint requests: G. Pacini, LADSEB-CNR, Corso Stati Uniti, 4, 35127 Padova, Italy. Romano Nosadini is also affiliated with the Institute of Internal Medicine and with the CNR Centre for Studies on Aging, University of Padova. Maria Sambataro is currently affiliated with the Division of Medicine of the Hospital of Porto Viro (Rovigo). A portion of this work was presented at the 32nd Congress of the European Association for the Study of Diabetes in Vienna, Austria (September 1996) and was published as abstract 600 in Diabetologia 39, Suppl . 1: 158A, 1996. Copyright © 1998 the American Physiological Society

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Apr 1, 1998

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