Abstract The minimal model is widely used to evaluate insulin action on glucose disappearance from frequently sampled intravenous glucose tolerance tests (FSIGT). The common protocols are a regular (rFSIGT, single injection of 0.3 g/kg of glucose) and an insulin-modified test (mFSIGT, with an additional insulin administration at 20 min). This study compared the insulin sensitivity index (S I ) and glucose effectiveness (S G ) obtained in the same individual (16 normal subjects) with the two tests. S I was 7.11 ± 0.80 10 −4 ⋅ min −1 ⋅ μU −1 ⋅ ml in rFSIGT and 6.96 ± 0.83 in mFSIGT ( P = 0.656), regression r = 0.92, P < 0.0001; S G was 0.0260 ± 0.0028 min −1 and 0.0357 ± 0.0052, respectively, statistically different ( P = 0.013) but still with a good regression ( r = 0.66, P = 0.0051). S G and insulin amount during the early period correlated ( r = 0.6, P = 0.015 in rFSIGT and r = 0.76, P = 0.0006 in mFSIGT). In summary, both FSIGTs with minimal model analysis provide the same S I , which is a very robust index. S G was different by 28% due probably to the relationship between S G and the amount of circulating insulin. In studies comparing groups, the simpler rFSIGT can still be used with the advantage of accounting for endogenous insulin, thus offering the possibility of direct inferences on the β-cell activity. frequently sampled intravenous glucose tolerance test glucose tolerance minimal model protocols insulin action Footnotes Address for reprint requests: G. Pacini, LADSEB-CNR, Corso Stati Uniti, 4, 35127 Padova, Italy. Romano Nosadini is also affiliated with the Institute of Internal Medicine and with the CNR Centre for Studies on Aging, University of Padova. Maria Sambataro is currently affiliated with the Division of Medicine of the Hospital of Porto Viro (Rovigo). A portion of this work was presented at the 32nd Congress of the European Association for the Study of Diabetes in Vienna, Austria (September 1996) and was published as abstract 600 in Diabetologia 39, Suppl . 1: 158A, 1996. Copyright © 1998 the American Physiological Society
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Apr 1, 1998
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera