Insulin binding and receptor tyrosine kinase activity in skeletal muscle of carnivorous and omnivorous fish

Insulin binding and receptor tyrosine kinase activity in skeletal muscle of carnivorous and... 0363-6119/94 $3.00 Copyright membrane. The receptor in all vertebrate species studied so far, including a primitive Agnathan hagfish, is a heterotetramer containing two extracellular a-subunits and two transmembrane p-subunits (9). When binds to the a-subunits, a conformational change takes place, which activates tyrosine kinase activity of the cytoplasmatic domain of the P-subunits, initiating a phosphorylation cascade that leads eventually to signal transduction (19). The process can be modulated by changes in receptor capacity and affinity as well and in tyrosine kinase activity. Decline of one or more of these parameters has been found in -resistant (obese) mammals (7, 25) and in humans with non--dependent diabetes mellitus (NIDDM) (7, 11). In contrast, either fasting or high-carbohydrate diet caused in mammals an upregulation of both binding capacity and tyrosine kinase activity of (3,lO). -receptor binding in liver, and heart , brain, red blood cells, and gonads has been studied in variety of fish species (13, 16, 17, 22, 27, 28, 30). Autophosphorylation of the receptor of the stingray Dasyatis americana liver and lamprey Lampetra fZuviatilis liver have been reported (32, 24), and the phosphorylation of exogenous substrates by receptor of carp ovaries was demonstrated (16). Although Leibush (22) has compared http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Insulin binding and receptor tyrosine kinase activity in skeletal muscle of carnivorous and omnivorous fish

Loading next page...
 
/lp/the-american-physiological-society/insulin-binding-and-receptor-tyrosine-kinase-activity-in-skeletal-rveVoGDH1f
Publisher
The American Physiological Society
Copyright
Copyright © 1994 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
See Article on Publisher Site

Abstract

0363-6119/94 $3.00 Copyright membrane. The receptor in all vertebrate species studied so far, including a primitive Agnathan hagfish, is a heterotetramer containing two extracellular a-subunits and two transmembrane p-subunits (9). When binds to the a-subunits, a conformational change takes place, which activates tyrosine kinase activity of the cytoplasmatic domain of the P-subunits, initiating a phosphorylation cascade that leads eventually to signal transduction (19). The process can be modulated by changes in receptor capacity and affinity as well and in tyrosine kinase activity. Decline of one or more of these parameters has been found in -resistant (obese) mammals (7, 25) and in humans with non--dependent diabetes mellitus (NIDDM) (7, 11). In contrast, either fasting or high-carbohydrate diet caused in mammals an upregulation of both binding capacity and tyrosine kinase activity of (3,lO). -receptor binding in liver, and heart , brain, red blood cells, and gonads has been studied in variety of fish species (13, 16, 17, 22, 27, 28, 30). Autophosphorylation of the receptor of the stingray Dasyatis americana liver and lamprey Lampetra fZuviatilis liver have been reported (32, 24), and the phosphorylation of exogenous substrates by receptor of carp ovaries was demonstrated (16). Although Leibush (22) has compared

Journal

AJP - Regulatory, Integrative and Comparative PhysiologyThe American Physiological Society

Published: Jun 1, 1994

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off