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Inhibition of Prothrombin Activation With Dextran

Inhibition of Prothrombin Activation With Dextran With Dextnzd WALTER G. LEVINE AND SHIRLEY of Physiology and Pharmacology, Wayne Michigan A. JOHNUniversity WALTER H. SEEGERS, SON. From the Department College of Medicine, Detroit, THE EXTENSIVE literature related to as a plasma volume expander earlier investigators made no mention of problems related to hemostasis and blood coagulation. Recent reports, however, indicate that circumstances may arise in association with the use of which lead to concern about bleeding tendencies (I). Difficulties follow the use of massive quantities of . In experimental work the clotting time of dog blood was found to be significantly increased after the addition of , both in vitro and after intravenous infusion (2). In guinea pigs an increased clotting time has been observed after repeated infusions (3). On the other hand, there is a study recorded in which was given to patients in amounts of 500 to 1,500 ml. without observing significant bleeding time changes(4). Previous studies have given no indication as to the possible mechanisms might be involved with. Our interest was from the viewpoint of in vitro studies, and after some preliminary experiments it became evident that there were certain manifestations related to platelet and platelet derivatives that might be of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

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Publisher
The American Physiological Society
Copyright
Copyright © 1955 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
See Article on Publisher Site

Abstract

With Dextnzd WALTER G. LEVINE AND SHIRLEY of Physiology and Pharmacology, Wayne Michigan A. JOHNUniversity WALTER H. SEEGERS, SON. From the Department College of Medicine, Detroit, THE EXTENSIVE literature related to as a plasma volume expander earlier investigators made no mention of problems related to hemostasis and blood coagulation. Recent reports, however, indicate that circumstances may arise in association with the use of which lead to concern about bleeding tendencies (I). Difficulties follow the use of massive quantities of . In experimental work the clotting time of dog blood was found to be significantly increased after the addition of , both in vitro and after intravenous infusion (2). In guinea pigs an increased clotting time has been observed after repeated infusions (3). On the other hand, there is a study recorded in which was given to patients in amounts of 500 to 1,500 ml. without observing significant bleeding time changes(4). Previous studies have given no indication as to the possible mechanisms might be involved with. Our interest was from the viewpoint of in vitro studies, and after some preliminary experiments it became evident that there were certain manifestations related to platelet and platelet derivatives that might be of

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: May 1, 1955

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