Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage

Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage METHODS Methods for MCA occlusion, for determination of infarct size, for measurement of NOS activity have been described in detail in previous publications (11, 12, 28) will only be summarized. General Surgical Procedures THERE IS A GROWING BODY of evidence that NO partici- pates in the mechanisms of (see Refs. 10 22 for a review). However, the role that NO plays in the pathogenesis of ischemic brain damage has not been clearly defined. NO is synthesized from L-arginine by NO synthase (NOS), an enzyme of which several isoforms have been identified (see Ref. 19 for a review). In brain, distinct isoforms of NOS are basally expressed, one in neurons another in endothelial cells (19). These constitutive isoforms of NOS (cNOS) produce NO R286 0363-6119/95 $3.00 Copyright o 1995 Studies were conducted on 53 male spontaneously hypertensive rats (Harl) weighing 300-400 g. Under halothane anesthesia (induction 5%, maintenance I%, in 100% oxygen), the left femoral artery was cannulated rats were placed on a stereotaxic frame (Kopf). Body temperature was maintained at 37 zt 0.5”C by a thermostatically controlled infrared lamp. The arterial catheter was connected to a pressure transducer the American Physiological Society R287 for recording of mean arterial http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
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Abstract

METHODS Methods for MCA occlusion, for determination of infarct size, for measurement of NOS activity have been described in detail in previous publications (11, 12, 28) will only be summarized. General Surgical Procedures THERE IS A GROWING BODY of evidence that NO partici- pates in the mechanisms of (see Refs. 10 22 for a review). However, the role that NO plays in the pathogenesis of ischemic brain damage has not been clearly defined. NO is synthesized from L-arginine by NO synthase (NOS), an enzyme of which several isoforms have been identified (see Ref. 19 for a review). In brain, distinct isoforms of NOS are basally expressed, one in neurons another in endothelial cells (19). These constitutive isoforms of NOS (cNOS) produce NO R286 0363-6119/95 $3.00 Copyright o 1995 Studies were conducted on 53 male spontaneously hypertensive rats (Harl) weighing 300-400 g. Under halothane anesthesia (induction 5%, maintenance I%, in 100% oxygen), the left femoral artery was cannulated rats were placed on a stereotaxic frame (Kopf). Body temperature was maintained at 37 zt 0.5”C by a thermostatically controlled infrared lamp. The arterial catheter was connected to a pressure transducer the American Physiological Society R287 for recording of mean arterial

Journal

AJP - Regulatory, Integrative and Comparative PhysiologyThe American Physiological Society

Published: Jan 1, 1995

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