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METHODS DESIGNED to examine the diurnal sensitivity metabolism to the habitual protein intake level (25) we showed that mediates protein deposition through a combination of changes in whole body protein synthesis and degradation that vary as a function of the protein content of the meal (23). isocaloric weight-maintaining diets, containing a wide range levels (0.33-2.3 g*kg+day--l), was invariably associated with suppression degradation that increased with protein intake (23). In contrast, the response of the nonoxidative disposal component of leucine flux, i.e., protein synthesis, was variable. At the lowest level of dietary protein intake, protein synthesis was inhibited, whereas at intakes of 1.5 g/kg and above protein synthesis was promoted. We interpreted these data as indicating two components of the response. One component was associated with provision of energy that acted to inhibit protein degradation, an effect likely to be mediated through insulin secretion. This is consistent with many studies that indicate that inhibition of proteolysis is a major IN STUDIES E282 0193-1849/96 $5.00 Copyright o 1996 Experimental design. Ten male subjects in good general health and with normal renal and hepatic function were studied. Their physical characteristics (means t SD) were age 32.7 2 12.9 yr, weight 70.4
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Feb 1, 1996
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