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Influence of fetal pulmonary epithelium on thrombin activity

Influence of fetal pulmonary epithelium on thrombin activity thrombin activity H. O’BRODOVICH, L. BERRY, M. D’COSTA, R. BURROWS, AND M. ANDREW Department of Paediatrics and Hospital for Sick Children Research Institute and Department of Biochemistry, Mt. Sinai Hospital, Torto, M5G 1X8 tario; and Departments of Obstetrics and Pediatrics, McMaster University Medical Centre, Hamilt, tario L8N 325, Canada numbers in the newborn (1, 16). Also, analysis of BAL fluid cannot identify the cellular source of its cstituent pro- and anticoagulant compounds. The present study was undertaken to investigate the cellular sources and mechanisms involved in the regulati of coagulati within the fetal and neatal space. It has determined the influence of the cell surface and secreted products of the pulmary, and specifically , epithelium thrombin generati. The ratiale for this study was that previous investigators demstrated that fetal rat type II epithelium grown in primary culture synthesizes glycosaminoglycan (GAG) ctaining molecules (25), and our laboratory (5) has recently demstrated that the A549 human tumor cell line, which originates from type II epithelium, has marked anticoagulant properties. It is well established that epithelial cells synthesize and release GAG compounds. However, this does not mean that these GAGS can augment antithrombin activity, since some GAGS (e.g., hyaluric acid) have http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Lung Cellular and Molecular Physiology The American Physiological Society

Influence of fetal pulmonary epithelium on thrombin activity

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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
1040-0605
eISSN
1522-1504
Publisher site
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Abstract

thrombin activity H. O’BRODOVICH, L. BERRY, M. D’COSTA, R. BURROWS, AND M. ANDREW Department of Paediatrics and Hospital for Sick Children Research Institute and Department of Biochemistry, Mt. Sinai Hospital, Torto, M5G 1X8 tario; and Departments of Obstetrics and Pediatrics, McMaster University Medical Centre, Hamilt, tario L8N 325, Canada numbers in the newborn (1, 16). Also, analysis of BAL fluid cannot identify the cellular source of its cstituent pro- and anticoagulant compounds. The present study was undertaken to investigate the cellular sources and mechanisms involved in the regulati of coagulati within the fetal and neatal space. It has determined the influence of the cell surface and secreted products of the pulmary, and specifically , epithelium thrombin generati. The ratiale for this study was that previous investigators demstrated that fetal rat type II epithelium grown in primary culture synthesizes glycosaminoglycan (GAG) ctaining molecules (25), and our laboratory (5) has recently demstrated that the A549 human tumor cell line, which originates from type II epithelium, has marked anticoagulant properties. It is well established that epithelial cells synthesize and release GAG compounds. However, this does not mean that these GAGS can augment antithrombin activity, since some GAGS (e.g., hyaluric acid) have

Journal

AJP - Lung Cellular and Molecular Physiology – The American Physiological Society

Published: Oct 1, 1991

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