Influence of brain injury on opioid-induced pial artery vasodilation

Influence of brain injury on opioid-induced pial artery vasodilation Thorogood, M. C., W. M. Armstead. Influence of on -induced pial artery . Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H1776-H1783,1995.This study was designed to investigate the effect of fluid percussion on -induced pial artery in the newborn pig. Previous observations have shown that produces pial artery vasoconstriction associated with elevated cerebral spinal fluid (CSF) levels in the piglet. Additionally, s produce pial that is attenuated by the nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine (L-NNA). Anesthetized newborn pigs equipped with a closed cranial window were connected to a percussion device consisting of a saline-filled cylindrical reservoir with a metal pendulum. of moderate severity (1.9-2.3 atm) was produced by allowing the pendulum to strike a piston on the cylinder. Methionine enkephalin (Met), an endogenous F- agonist in physiological pharmacological concentrations (lo- lo , 10e8, 10s6 M), produced that was attenuated following (7 ? 1 vs. 3 2 l%, 11 2 1 vs. 5 t 1% 16 t 1 vs. 8 t 1% for lo-lo, 10m8, low6 M Met b e f ore after , respectively, IL = 5). Met-induced dilation was associated with increased cortical periarachnoid CSF guanosine 3’,5’-cyclic monophosphate (cGMP), these biochemical changes were blunted by (342 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Influence of brain injury on opioid-induced pial artery vasodilation

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
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Abstract

Thorogood, M. C., W. M. Armstead. Influence of on -induced pial artery . Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H1776-H1783,1995.This study was designed to investigate the effect of fluid percussion on -induced pial artery in the newborn pig. Previous observations have shown that produces pial artery vasoconstriction associated with elevated cerebral spinal fluid (CSF) levels in the piglet. Additionally, s produce pial that is attenuated by the nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine (L-NNA). Anesthetized newborn pigs equipped with a closed cranial window were connected to a percussion device consisting of a saline-filled cylindrical reservoir with a metal pendulum. of moderate severity (1.9-2.3 atm) was produced by allowing the pendulum to strike a piston on the cylinder. Methionine enkephalin (Met), an endogenous F- agonist in physiological pharmacological concentrations (lo- lo , 10e8, 10s6 M), produced that was attenuated following (7 ? 1 vs. 3 2 l%, 11 2 1 vs. 5 t 1% 16 t 1 vs. 8 t 1% for lo-lo, 10m8, low6 M Met b e f ore after , respectively, IL = 5). Met-induced dilation was associated with increased cortical periarachnoid CSF guanosine 3’,5’-cyclic monophosphate (cGMP), these biochemical changes were blunted by (342

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Nov 1, 1995

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