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ZHEN YAN, STANLEY MARC T. HAMILTON, Department of Integrative Houston, Texas 77225; University of Liverpool, SALMONS, YAN LI DANG, AND FRANK W. BOOTH Biology, University of Texas Medical School, and Department of Human Anatomy and Cell Biology, Liverpool L69 3BX, United Kingdom treadmill running (15) and in vivo (10) and is directly correlated with the musclesâ oxidative capacity and the animalâs endurance capacity (15). Thus it is important to elucidate mechanisms underlying the control of cytochrome c gene expression. Treadmill running exercise had no detectable effect on the transcription rates of the cytochrome c gene, as determined by nuclear run-on assays by Neufer and Dohm (36). In our preliminary experiments, ally stimulated muscles showed no increase in the activity of a reporter gene driven by the promoter (-726 to +610) of the rat somatic cytochrome c gene (data not shown). We therefore began to investigate possible activity-responsive elements in its 3â-untranslated region (UTR). Because mRNAlocalization (44) and stability (43) and protein translation (48) may all be regulated by the between cytoplasmic proteins and the mRNA in the control of gene expression, we hypothesized that there was a sequence-specific cytochrome c mRNA-protein in the cytoplasm of skeletal muscle, which
AJP - Cell Physiology – The American Physiological Society
Published: Oct 1, 1996
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