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Increased contractile activity decreases RNA-protein interaction in the 3'-UTR of cytochrome c mRNA

Increased contractile activity decreases RNA-protein interaction in the 3'-UTR of cytochrome c mRNA ZHEN YAN, STANLEY MARC T. HAMILTON, Department of Integrative Houston, Texas 77225; University of Liverpool, SALMONS, YAN LI DANG, AND FRANK W. BOOTH Biology, University of Texas Medical School, and Department of Human Anatomy and Cell Biology, Liverpool L69 3BX, United Kingdom treadmill running (15) and in vivo (10) and is directly correlated with the muscles’ oxidative capacity and the animal’s endurance capacity (15). Thus it is important to elucidate mechanisms underlying the control of cytochrome c gene expression. Treadmill running exercise had no detectable effect on the transcription rates of the cytochrome c gene, as determined by nuclear run-on assays by Neufer and Dohm (36). In our preliminary experiments, ally stimulated muscles showed no increase in the activity of a reporter gene driven by the promoter (-726 to +610) of the rat somatic cytochrome c gene (data not shown). We therefore began to investigate possible activity-responsive elements in its 3’-untranslated region (UTR). Because mRNAlocalization (44) and stability (43) and protein translation (48) may all be regulated by the between cytoplasmic proteins and the mRNA in the control of gene expression, we hypothesized that there was a sequence-specific cytochrome c mRNA-protein in the cytoplasm of skeletal muscle, which http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Increased contractile activity decreases RNA-protein interaction in the 3'-UTR of cytochrome c mRNA

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Publisher
The American Physiological Society
Copyright
Copyright © 1996 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
Publisher site
See Article on Publisher Site

Abstract

ZHEN YAN, STANLEY MARC T. HAMILTON, Department of Integrative Houston, Texas 77225; University of Liverpool, SALMONS, YAN LI DANG, AND FRANK W. BOOTH Biology, University of Texas Medical School, and Department of Human Anatomy and Cell Biology, Liverpool L69 3BX, United Kingdom treadmill running (15) and in vivo (10) and is directly correlated with the muscles’ oxidative capacity and the animal’s endurance capacity (15). Thus it is important to elucidate mechanisms underlying the control of cytochrome c gene expression. Treadmill running exercise had no detectable effect on the transcription rates of the cytochrome c gene, as determined by nuclear run-on assays by Neufer and Dohm (36). In our preliminary experiments, ally stimulated muscles showed no increase in the activity of a reporter gene driven by the promoter (-726 to +610) of the rat somatic cytochrome c gene (data not shown). We therefore began to investigate possible activity-responsive elements in its 3’-untranslated region (UTR). Because mRNAlocalization (44) and stability (43) and protein translation (48) may all be regulated by the between cytoplasmic proteins and the mRNA in the control of gene expression, we hypothesized that there was a sequence-specific cytochrome c mRNA-protein in the cytoplasm of skeletal muscle, which

Journal

AJP - Cell PhysiologyThe American Physiological Society

Published: Oct 1, 1996

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