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Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension

Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension Ehrlich ascites carcinoma (EAT) (4, 16, 21). We have established that the average FA requirement of this tumor for net growth, when its size is about 7 ml, is approximately 10 nmol FA/min (2), but it is not clear whether to what extent additional FA are required as metabolic fuel. Numerous estimates of FFA rates EAT both in vitro (23) in vivo have been published (11,16,17). In each case the rates this tumor were much greater than the estimated net rate of FFA esterification during tumor growth in vivo. However, there is reason to doubt the validity of this conclusion, because a fully grown EAT exists in an essentially anaerobic milieu (9,20). It seems especially unlikely that the high rates of that were measured+ in vitro in air (23) could be maintained the EAT at the low oxygen tensions that have been reported in vivo. The high rates of FFA EAT in vivo (17) were obtained using [9,10-3H] measuring the formation of 3Hz0. We assumed that the latter product was a measure of complete of FA to CO2 HzO. This assumption seemed plausible, since desaturation of [9,10-3H] to monounsaturated FA was shown to produce negligible quantities of 3H20 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension

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Publisher
The American Physiological Society
Copyright
Copyright © 1983 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
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Abstract

Ehrlich ascites carcinoma (EAT) (4, 16, 21). We have established that the average FA requirement of this tumor for net growth, when its size is about 7 ml, is approximately 10 nmol FA/min (2), but it is not clear whether to what extent additional FA are required as metabolic fuel. Numerous estimates of FFA rates EAT both in vitro (23) in vivo have been published (11,16,17). In each case the rates this tumor were much greater than the estimated net rate of FFA esterification during tumor growth in vivo. However, there is reason to doubt the validity of this conclusion, because a fully grown EAT exists in an essentially anaerobic milieu (9,20). It seems especially unlikely that the high rates of that were measured+ in vitro in air (23) could be maintained the EAT at the low oxygen tensions that have been reported in vivo. The high rates of FFA EAT in vivo (17) were obtained using [9,10-3H] measuring the formation of 3Hz0. We assumed that the latter product was a measure of complete of FA to CO2 HzO. This assumption seemed plausible, since desaturation of [9,10-3H] to monounsaturated FA was shown to produce negligible quantities of 3H20

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: Jan 1, 1983

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