MAYHAN, ent dilatation WILLIAM G. Impairment of endothelium-dependof during mellitus. Am. 46619),with the use of intravital microscopy in control (nondiabetic) diabetic rats. ADP (lOa M) increasedpial arteriolar diameter by 13 t 1% (mean * SE) in control rats did not changediameter of in diabetic rats (1 t 1%). Serotonin (10B5 increaseddiameter of by M) 9 + 1% in control rats constricted by 5 t 2% in diabetic rats. Nitroglycerin produced similar dilatation of in control diabetic rats, suggestingthat impaired dilatation of in diabetic rats was not related to nonspecific impairment of vasodilatation. The thromboxane analogueU-46619 produced similar constriction of in control diabetic rats. Thus endothelium-dependent dilatation of in response torADP serotonin is profoundly impaired in diabetic rats. adenosinediphosphate;serotonin; thromboxane; nitroglycerin; platelets; stroke; brain; microcirculation; rats METHODS MELLITUS produces abnormalities in the microcirculation of many vascular beds. Morphologically, produces thickening of the capillary basement membrane (2,14,17), a decrease in the density of microvessels (3), endothelial cell degeneration (7, 25), an increase in platelet adhesion aggregation (12, 22, 29). Functionally, produces an increase in vascular permeability (15, 27), recent evidence suggests that endothelium-dependent responses of the aorta are impaired in diabetic rats (9, 23, 26, 31). appears to be a
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Mar 1, 1989
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