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Impact of cortical plasticity on information signaled by populations of neurons in the cerebral cortex

Impact of cortical plasticity on information signaled by populations of neurons in the cerebral... Abstract The performance of neural codes to represent attributes of sensory signals has been evaluated in the vertebrate peripheral and central nervous system. Here, we determine how information signaled by populations of neurons is modified by plasticity. Suprathreshold neuronal responses from a large number of neurons were recorded in the juvenile mouse barrel cortex using dithered random-access scanning. Pairing of one input with another resulted in a long-lasting, input-specific modification of the cortical responses. Mutual information analysis indicated that cortical plasticity efficiently changed information signaled by populations of neurons. The contribution of neural correlations to the change in mutual information was negative. The largest factor limiting fidelity of mutual information after pairing was a low reliability of the modified cortical responses. functional calcium imaging barrel cortex random-access scanning mesoscale spatiotemporal patterns of activity Copyright © 2011 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print June 2011 , doi: 10.​1152/​jn.​01001.​2010 AJP - JN Physiol September 2011 vol. 106 no. 3 1118-1124 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: jn.01001.2010v1 106/3/1118 most recent Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Pita-Almenar, J. D. Articles by Koester, H. J. PubMed PubMed citation Articles by Pita-Almenar, J. D. Articles by Koester, H. J. Related Content Load related web page information Current Issue September 2011, 106 (3) Alert me to new issues of AJP - JN Physiol About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2011 the American Physiological Society Print ISSN: 0022-3077 Online ISSN: 1522-1598 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

Impact of cortical plasticity on information signaled by populations of neurons in the cerebral cortex

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References (44)

Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
DOI
10.1152/jn.01001.2010
pmid
21653720
Publisher site
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Abstract

Abstract The performance of neural codes to represent attributes of sensory signals has been evaluated in the vertebrate peripheral and central nervous system. Here, we determine how information signaled by populations of neurons is modified by plasticity. Suprathreshold neuronal responses from a large number of neurons were recorded in the juvenile mouse barrel cortex using dithered random-access scanning. Pairing of one input with another resulted in a long-lasting, input-specific modification of the cortical responses. Mutual information analysis indicated that cortical plasticity efficiently changed information signaled by populations of neurons. The contribution of neural correlations to the change in mutual information was negative. The largest factor limiting fidelity of mutual information after pairing was a low reliability of the modified cortical responses. functional calcium imaging barrel cortex random-access scanning mesoscale spatiotemporal patterns of activity Copyright © 2011 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print June 2011 , doi: 10.​1152/​jn.​01001.​2010 AJP - JN Physiol September 2011 vol. 106 no. 3 1118-1124 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: jn.01001.2010v1 106/3/1118 most recent Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Pita-Almenar, J. D. Articles by Koester, H. J. PubMed PubMed citation Articles by Pita-Almenar, J. D. Articles by Koester, H. J. Related Content Load related web page information Current Issue September 2011, 106 (3) Alert me to new issues of AJP - JN Physiol About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2011 the American Physiological Society Print ISSN: 0022-3077 Online ISSN: 1522-1598 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

Journal

Journal of Neurophysiology – The American Physiological Society

Published: Sep 1, 2011

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