Kihara, Mikihiro, Paula 3. Zollman, Inge L. Smithson, Terrence D. Lagerlund, and Phillip A. Low. of exogenous on normal and diabetic peripheral nerve. Am. J. Physiol. 266 (EndocrinoZ. Metab. 29): E980E985, 1994.- administration can cause or worsen experimental and human diabetic neuropathy (â neuritisâ). In this study, we tested the hypothesis that administration impairs tissue oxygenation. We infused under nonhypoglycemic conditions and evaluated its on endoneurial oxygen tension, nerve blood flow, and the oxyhemoglobin dissociation curve of peripheral nerve in normal and diabetic rats. Intravenous infusion resulted in a dosedependent reduction in endoneurial oxygen tension in normal nerves (from 26% at 0.04 U/kg to 55% at 32 U/kg). The nerves of rats with streptozotocin-induced diabetes were resistant, but with control of hyperglycemia this susceptibility to the endoneurial of returned. The reduction in endoneurial oxygen tension regressed with glycosylated hemoglobin (Y = 53.8 - 2.7X, where Y = %reduction in endoneurial oxygen tension andX = HbAi; r = 0.87; P = 16.7 mmol/l at the time of harvest. treatment was administered subcutaneously according to the ratâs blood glucose level, measured just before ultralente administration. was administered two times daily at 0800 and 1700 h (Table 3). Acute intravenous administration.
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Jun 1, 1994
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