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Hypoxia does not increase CSF or plasma beta-endorphin activity

Hypoxia does not increase CSF or plasma beta-endorphin activity FREEDMAN, REW, ANTHONY 1”. SCARDELLA, NORMAN H. EDELMAN, TEQDORI) V. SANTIAGO.H~~OX~CZ does noa: increase CSF or plasma /3-endorphin activity. J. Appl. Physiol. 64(3): 966-971, 1988.---The ability of moderate (30-50 Torr arterial Paz) severe (~30 Torr arterial PoJ to generate that modulate ventilation was studied in unanesthetized goats. Ventilation its components, arterial blood gas tensions pH, plasma cerebrospinal fluid (CSF) ,&endorphin activity were measured before after 4 h of sustained moderate or severe . Ventilation, as expected, increased with . There were no significant changes in either plasma or CSF ,8-endorphin activity after sustained . To rule out elaboration of other than /?-endorphin after , naloxone or saline was administered to five of the seven goats exposed to 4 h of severe , their ventilatory responses were compared for 30 additional min of hypoxic breathing. No significant differences in ventilation occurred in the two treatment graups during this time period. We conclude that, unlike increases in airway resistance, moderate severe do not cause the elaboration of that modify respiratory output in unanesthetized adult goats. The apparent ability of to cause elaboration of in the neonate may represent a maturational phenomenon. ; opioid peptides; naloxone; ventilation could cause the elaboration http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Hypoxia does not increase CSF or plasma beta-endorphin activity

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Publisher
The American Physiological Society
Copyright
Copyright © 1988 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

FREEDMAN, REW, ANTHONY 1”. SCARDELLA, NORMAN H. EDELMAN, TEQDORI) V. SANTIAGO.H~~OX~CZ does noa: increase CSF or plasma /3-endorphin activity. J. Appl. Physiol. 64(3): 966-971, 1988.---The ability of moderate (30-50 Torr arterial Paz) severe (~30 Torr arterial PoJ to generate that modulate ventilation was studied in unanesthetized goats. Ventilation its components, arterial blood gas tensions pH, plasma cerebrospinal fluid (CSF) ,&endorphin activity were measured before after 4 h of sustained moderate or severe . Ventilation, as expected, increased with . There were no significant changes in either plasma or CSF ,8-endorphin activity after sustained . To rule out elaboration of other than /?-endorphin after , naloxone or saline was administered to five of the seven goats exposed to 4 h of severe , their ventilatory responses were compared for 30 additional min of hypoxic breathing. No significant differences in ventilation occurred in the two treatment graups during this time period. We conclude that, unlike increases in airway resistance, moderate severe do not cause the elaboration of that modify respiratory output in unanesthetized adult goats. The apparent ability of to cause elaboration of in the neonate may represent a maturational phenomenon. ; opioid peptides; naloxone; ventilation could cause the elaboration

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Mar 1, 1988

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