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Histamine tachyphylaxis in canine airways despite prostaglandin synthesis inhibition

Histamine tachyphylaxis in canine airways despite prostaglandin synthesis inhibition ANL, PAULJ., SUSAN J. @UNST,ANDROBERTE.HYATT. cane despiteprostagland synthesis hibition. J. Appl. Physiol. 65(5): 1944-1949,1988. aerosolized was studied dogs anesthetized with thiamylal after pretreatment with prostagland synthesis hibirs. Three consecutive doseresponse curves were obtaed ne dogs pretreated with 5 mg/kg domethac; two of these ne were also pretreated with 10 mg/kg domethac. Seven of the ne dogs were pretreated with 4 mg/kg sodium meclofenamate; four of these seven were also pretreated with 12 mg/kg. All dogs had at high concentrations of regardless of hibir used. Pretreatment with domethac while the dogs were under a-chloralose-urethan anesthesia gave similar results. was also studied both the presence and the absence of domethac tracheal smooth muscle strips obtaed from seven additional dogs. A decrease the median effective dose was observed the domethac-treated strips, but, remaed. We conclude that prostagland synthesis hibition does not reverse either vivo or c vitro. Thus the mechanism of remas unexplaed. airway desensitization; domethac; thetic agent; tracheal smooth muscle meclofenamate; anes- alose-urethan was used as the primary anesthetic was also studied. addition, the effect of PG hibition on HT vitro was studied. METHODS Vivo Studies The methods and procol used this paper have been detailed previously (5). Briefly, healthy http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Histamine tachyphylaxis in canine airways despite prostaglandin synthesis inhibition

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Publisher
The American Physiological Society
Copyright
Copyright © 1988 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

ANL, PAULJ., SUSAN J. @UNST,ANDROBERTE.HYATT. cane despiteprostagland synthesis hibition. J. Appl. Physiol. 65(5): 1944-1949,1988. aerosolized was studied dogs anesthetized with thiamylal after pretreatment with prostagland synthesis hibirs. Three consecutive doseresponse curves were obtaed ne dogs pretreated with 5 mg/kg domethac; two of these ne were also pretreated with 10 mg/kg domethac. Seven of the ne dogs were pretreated with 4 mg/kg sodium meclofenamate; four of these seven were also pretreated with 12 mg/kg. All dogs had at high concentrations of regardless of hibir used. Pretreatment with domethac while the dogs were under a-chloralose-urethan anesthesia gave similar results. was also studied both the presence and the absence of domethac tracheal smooth muscle strips obtaed from seven additional dogs. A decrease the median effective dose was observed the domethac-treated strips, but, remaed. We conclude that prostagland synthesis hibition does not reverse either vivo or c vitro. Thus the mechanism of remas unexplaed. airway desensitization; domethac; thetic agent; tracheal smooth muscle meclofenamate; anes- alose-urethan was used as the primary anesthetic was also studied. addition, the effect of PG hibition on HT vitro was studied. METHODS Vivo Studies The methods and procol used this paper have been detailed previously (5). Briefly, healthy

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Nov 1, 1988

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