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Hepatic biotransformation of two hydroxy-7-oxotaurine-conjugated bile acids in the dog

Hepatic biotransformation of two hydroxy-7-oxotaurine-conjugated bile acids in the dog the orientation of the 7-hydroxy group has an influence on the physiological properties of acids. Chenodeoxycholic acid, which has a 7cr-hydroxy group, causes epitheliolysis and induces water secretion from the colon at concentrations of 3-10 mM, whereas its 7p epimer, ursodeoxycholic acid, is inert at these concentrations (9). Removal of the 7-hydroxyl group from these compounds results in the formation of lithocholic acid, a potent hepatotoxin in experimental animals (39). The bacterial flora of the distal intestine contain many 7-hydroxysteroid dehydrogenases which dehydrogenate the 7~ or ‘I@-hydroxy group of the two major acids to form 7-0~0 acids (3, 18, 21, 30). Despite the formation of thesecompounds, which is well documented in humans (12, 13, 20), and despite the convincing evidence that some acids are absorbed from the colon (34, 35), 7-0~0 acids are rarely detected in in humans in appreciable amounts (19, 25). This suggests that either 700x0 acids are not absorbed from the colon or, if absorbed, are reduced to 7-hydroxy acids during hepatic passage. Indeed, efficient and stereospecific reduction of 3cu-hydroxy-7-oxocholanoic acid, the 70x0 derivative of chenodeoxycholic acid, was recently well documented for humans by Fromm et al. (15), confirg and extending previous work in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Hepatic biotransformation of two hydroxy-7-oxotaurine-conjugated bile acids in the dog

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Publisher
The American Physiological Society
Copyright
Copyright © 1983 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
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Abstract

the orientation of the 7-hydroxy group has an influence on the physiological properties of acids. Chenodeoxycholic acid, which has a 7cr-hydroxy group, causes epitheliolysis and induces water secretion from the colon at concentrations of 3-10 mM, whereas its 7p epimer, ursodeoxycholic acid, is inert at these concentrations (9). Removal of the 7-hydroxyl group from these compounds results in the formation of lithocholic acid, a potent hepatotoxin in experimental animals (39). The bacterial flora of the distal intestine contain many 7-hydroxysteroid dehydrogenases which dehydrogenate the 7~ or ‘I@-hydroxy group of the two major acids to form 7-0~0 acids (3, 18, 21, 30). Despite the formation of thesecompounds, which is well documented in humans (12, 13, 20), and despite the convincing evidence that some acids are absorbed from the colon (34, 35), 7-0~0 acids are rarely detected in in humans in appreciable amounts (19, 25). This suggests that either 700x0 acids are not absorbed from the colon or, if absorbed, are reduced to 7-hydroxy acids during hepatic passage. Indeed, efficient and stereospecific reduction of 3cu-hydroxy-7-oxocholanoic acid, the 70x0 derivative of chenodeoxycholic acid, was recently well documented for humans by Fromm et al. (15), confirg and extending previous work in the

Journal

AJP - Gastrointestinal and Liver Physiology – The American Physiological Society

Published: Sep 1, 1983

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