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MARK V., JEFFREY D. HOSENPUD, A. ROGER AND MARK J. MORTON. Hemodynamics and sex steroid administration in guinea pigs. Am. J. Physiol. 249 (Regulatory Integrative Comp. Physiol. 18): R179-Rl85, 1985.-We investigated the time course and possible mechanisms by which the maternal cardiovascular system adapts to the demands of . Control, 20-, 40-, and 60-day gestation guinea pigs (total 68 days) and nonpregnant virgin female guinea pigs chronically dosed with cholesterol (control), estrogen (17@-), progesterone, and estrogen plus progesterone were studied. In vivo heart rates, pressures, s, blood volumes, and in vitro left ventricular pressurevolume relations were measured. There was no difference in heart rate, mean arterial, right atrial, or left ventricular enddiastolic pressures, or left ventricular weights between the various pregnant animals or hormone-dosed animals and their respective controls. By 20 days gestation blood volume (24%, P < 0.005), (22%, P < O.OOS), and stroke volume (22%, P < 0.05) were increased, whereas uterine blood flow was unchanged. Chronic estrogen administration resulted in similar increases in (24%, P < 0.05), stroke volume (31%, P < 0.05), and blood volume (l3%, P < 0.05). In vitro left ventricular pressure-volume relations were shifted to the right in all pregnant and
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Aug 1, 1985
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