of D. BARON of Endocrinology and Metabolism, Department of Medicine, University School of Medicine, Indianapolis 46202-5124; Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Baron, Alain D. Hemodynamic actions of . Am. J. Physiol. 267 (Endocrinol. Metab. 30): E187-E202, 1994.-There is accumulating evidence that has a physiological role to vasodilate skeletal muscle vasculature in humans. This effect occurs in a dose-dependent fashion within a half-maximal response of - 40 pU/ml. This vasodilating action is impaired in states of resistance such as obesity, non-dependent diabetes, and elevated blood pressure. The precise physiological role of -mediated vasodilation is not known. Data indicate that the degree of skeletal muscle perfusion can be an important determinant of -mediated glucose uptake. Therefore, it is possible that mediated vasodilation is an integral aspect of âs overall action to stimulate glucose uptake; thus defective vasodilation could potentially contribute to resistance. In addition, -mediated vasodilation may play a role in the regulation of vascular tone. Data are provided to indicate that the pressor response to systemic norepinephrine infusions is increased in obese -resistant subjects. Moreover, the normal effect of to shift the norepinephrine pressor dose-response curve to the right is impaired in these patients. Therefore, impaired
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Aug 1, 1994
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