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Greater unidirectional calcium efflux from bone during metabolic, compared with respiratory, acidosis

Greater unidirectional calcium efflux from bone during metabolic, compared with respiratory,... NANCY S. KRIEGER of Rochester, Rochester, New York 14642 31): F425-F431, 1992.-There is a smaller net from bone in vitro during respiratory (increasedPco,) than metabolic (decreased [HCO;]) . This could be due to the elevated lko2, which would lessenthe driving force for mineral dissolution and increasethe driving force for mineralization respect to carbonatedapatite in the bone mineral. To test this hypothesis, we injected neonatal mice 45Caand dissectedthe radiolabeledcalvariae 24 h later. The live calvariae were then cultured for 24 h under conditions simulating respiratory (Resp,pH = 7.225 t 0.003, PCO~ = 87.5 t 0.1 ), severe respiratory (SResp, pH = 7.072 k 0.004, PCO* = 103.0 t 0.5 ), metabolic (Met, pH = 7.212 k 0.003, HCO, = 15.5 t 0.1 meq/l), or normal acid-basestatus (Ctl, pH = 7.452t 0.003, PCO~ = 40.0 t 0.2 , HCO; = 27.8 t 0.2 meq/l) and bidirectional net flux (JcJ and 4’Careleasewere determined. There wasgreater Jca from bone during Met than Resp,and Jca wasnot different from Met during SRespdespitethe latter having a significantly lower pH. There was greater 4’Ca releasefrom bone during Met than Resp,SResp,or Ctl. There wasa similar direct correlation betweenJca and 4”Ca in the respiratory and metabolic groups. However, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Renal Physiology The American Physiological Society

Greater unidirectional calcium efflux from bone during metabolic, compared with respiratory, acidosis

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Publisher
The American Physiological Society
Copyright
Copyright © 1992 the American Physiological Society
ISSN
0363-6127
eISSN
1522-1466
Publisher site
See Article on Publisher Site

Abstract

NANCY S. KRIEGER of Rochester, Rochester, New York 14642 31): F425-F431, 1992.-There is a smaller net from bone in vitro during respiratory (increasedPco,) than metabolic (decreased [HCO;]) . This could be due to the elevated lko2, which would lessenthe driving force for mineral dissolution and increasethe driving force for mineralization respect to carbonatedapatite in the bone mineral. To test this hypothesis, we injected neonatal mice 45Caand dissectedthe radiolabeledcalvariae 24 h later. The live calvariae were then cultured for 24 h under conditions simulating respiratory (Resp,pH = 7.225 t 0.003, PCO~ = 87.5 t 0.1 ), severe respiratory (SResp, pH = 7.072 k 0.004, PCO* = 103.0 t 0.5 ), metabolic (Met, pH = 7.212 k 0.003, HCO, = 15.5 t 0.1 meq/l), or normal acid-basestatus (Ctl, pH = 7.452t 0.003, PCO~ = 40.0 t 0.2 , HCO; = 27.8 t 0.2 meq/l) and bidirectional net flux (JcJ and 4’Careleasewere determined. There wasgreater Jca from bone during Met than Resp,and Jca wasnot different from Met during SRespdespitethe latter having a significantly lower pH. There was greater 4’Ca releasefrom bone during Met than Resp,SResp,or Ctl. There wasa similar direct correlation betweenJca and 4”Ca in the respiratory and metabolic groups. However,

Journal

AJP - Renal PhysiologyThe American Physiological Society

Published: Mar 1, 1992

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