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Fever: Role of Pyrogens and Cryogens

Fever: Role of Pyrogens and Cryogens MATTHEW Department of Physiology, University J. KLUGER Medical School, Ann Arbw, Michigan of Michigan I. II. III. IV. V. VI. VII. VIII. IX. X. XI. XII. I. INTRODUCTION Introduction ......................................................................................... Fever Defined ........................................................................................ Early Thoughts on the Nature of Fever ............................................................ Febrile Responses of Vertebrates and Invertebrates ............................................... Reported Failure to Induce Fever in Vertebrates .................................................. Adaptive Function of Fever ......................................................................... A. Fever and disease ................................................................................ B. Fever during nonpathological conditions ........................................................ Central Nervous System and Fever ................................................................. Methodological Problems in Fever Research Relating to Contamination With Endotoxin ........ A. Assumption 1: polymyxin B can be used to ensure that fever and immune responses are not attribu to endotoxin . . . . . . . . . . . . . . . . . . . . . . . . . . . ..*.................................*... B. Assumption 2: lipopolysaccharide fever can be distinguished from endogenous pyrogen fever by the shape of the fever curve . ..*........................................*................ C. Assumption 3: lipopolysaccharide fever can be distinguished from endogenous pyrogen fever by latency to onset of fever *......I..............*...*.......................*....*.....*... Putative Mediators of Fever (Endogenous Pyrogens) . . . . . . ..*.**.................*................ A. Interleukin lcu and interleukin l/3 *........*....*................................................ B. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reviews The American Physiological Society

Fever: Role of Pyrogens and Cryogens

Matthew J. Kluger
Physiological Reviews , Volume 71: 101 – Jan 1, 1991
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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
0031-9333
eISSN
1522-1210
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Abstract

MATTHEW Department of Physiology, University J. KLUGER Medical School, Ann Arbw, Michigan of Michigan I. II. III. IV. V. VI. VII. VIII. IX. X. XI. XII. I. INTRODUCTION Introduction ......................................................................................... Fever Defined ........................................................................................ Early Thoughts on the Nature of Fever ............................................................ Febrile Responses of Vertebrates and Invertebrates ............................................... Reported Failure to Induce Fever in Vertebrates .................................................. Adaptive Function of Fever ......................................................................... A. Fever and disease ................................................................................ B. Fever during nonpathological conditions ........................................................ Central Nervous System and Fever ................................................................. Methodological Problems in Fever Research Relating to Contamination With Endotoxin ........ A. Assumption 1: polymyxin B can be used to ensure that fever and immune responses are not attribu to endotoxin . . . . . . . . . . . . . . . . . . . . . . . . . . . ..*.................................*... B. Assumption 2: lipopolysaccharide fever can be distinguished from endogenous pyrogen fever by the shape of the fever curve . ..*........................................*................ C. Assumption 3: lipopolysaccharide fever can be distinguished from endogenous pyrogen fever by latency to onset of fever *......I..............*...*.......................*....*.....*... Putative Mediators of Fever (Endogenous Pyrogens) . . . . . . ..*.**.................*................ A. Interleukin lcu and interleukin l/3 *........*....*................................................ B.

Journal

Physiological Reviews – The American Physiological Society

Published: Jan 1, 1991

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