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Fast breaths, slow breaths, small breaths, big breaths: importance of vagal innervation in the newborn lung

Fast breaths, slow breaths, small breaths, big breaths: importance of vagal innervation in the... Fast breaths, slow breaths, small breaths, big breaths: importance of vagal innervation in the newborn lung Bradley Thach 1 Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110 it is well established that vagally innervated mechanoreceptors in the lung influence respiratory frequency and the occurrence of spontaneous sighs (augmented breaths). Are these reflexes vitally important, or do they merely “fine tune” the respiratory pattern? The remarkable vitality and long-term survival of human patients and laboratory animals after denervation associated with lung transplantation argues for the latter ( 3 , 7 ). The rapid onset of severe respiratory failure following vagotomy in neonatal animals argues for the former ( 5 ). In this month's issue of the Journal of Applied Physiology , Lalani and associates ( 8 ) provide convincing evidence of the necessity of vagal pulmonary innervation for pulmonary function in lambs. This work extends earlier studies from their laboratory ( 15 ), which documented severe pulmonary failure at birth in lambs following denervation in utero. In the present work, the preservation of laryngeal innervation and absence of anesthesia eliminate confounding factors that were present in prior neonatal models. Moreover, the new study provides a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Fast breaths, slow breaths, small breaths, big breaths: importance of vagal innervation in the newborn lung

Thach, Bradley
Journal of Applied Physiology , Volume 91 (5): 2298 – Nov 1, 2001
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Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
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Abstract

Fast breaths, slow breaths, small breaths, big breaths: importance of vagal innervation in the newborn lung Bradley Thach 1 Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110 it is well established that vagally innervated mechanoreceptors in the lung influence respiratory frequency and the occurrence of spontaneous sighs (augmented breaths). Are these reflexes vitally important, or do they merely “fine tune” the respiratory pattern? The remarkable vitality and long-term survival of human patients and laboratory animals after denervation associated with lung transplantation argues for the latter ( 3 , 7 ). The rapid onset of severe respiratory failure following vagotomy in neonatal animals argues for the former ( 5 ). In this month's issue of the Journal of Applied Physiology , Lalani and associates ( 8 ) provide convincing evidence of the necessity of vagal pulmonary innervation for pulmonary function in lambs. This work extends earlier studies from their laboratory ( 15 ), which documented severe pulmonary failure at birth in lambs following denervation in utero. In the present work, the preservation of laryngeal innervation and absence of anesthesia eliminate confounding factors that were present in prior neonatal models. Moreover, the new study provides a

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Nov 1, 2001

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