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LABYRINTH, K+ is thought to be secreted by dark cells into the luminal fluid, endolymph (17). K+ transport across the dark cell epithelium consists of K+ uptake across the basolateral membrane via the Na+-Cl--K+ cotransporter and the Na+-K+-ATPase (16,17,29). The of K+ exit across the apical membrane, however, is so far unknown. We have reported that dark cells swell rapidly when K+ is isosmotically elevated from 3.6 to 25 mM. Because K+-induced cell swelling was dependent on the presence of Cl- and Na+ and inhibited by piretanide, we concluded that K+induced cell swelling is dependent on the Na+-Cl--K+ cotransporter (29). Further, when K+ is isosmotically reduced from 25 to 3.6 mM, cell volume decreases rapidly (29). The present study was designed to characterize the for . It was of interest to learn whether shrinking occurred 1) via a reversal of the swelling process, i.e., via the Na+-Cl--K+ cotransporter, 2) via the K+ channel our laboratory found in the apical membrane (25), 3) via a yet undefined K+ exit pathway, or 4) via some other such as extrusion of organic compounds independent of ions. Our data, which demonstrate the ion selectivity as well as the drug sensitivity of the
AJP - Cell Physiology – The American Physiological Society
Published: Sep 1, 1992
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