Schultz, Jo El J., Elana Rose, Zhenhai Yao, Garrett J. Gross. Evidence for volvement of preconditiong s. Am. J. PhysioZ. 268 ( Circ. PhysioZ. 37): H2157-H2161, 1995.-The purpose of the present study was to vestigate a possible role of preconditiong (PC). To test this hypothesis, anesthetized, open-chest, male Wistar s were subjected to five different protocols. group I, the control group was subjected to 30 m of left coronary artery occlusion 2 h of reperfusion. group II, PC was elicited by three 5m occlusion periods terspersed with 5 m of reperfusion. group III, naloxone (NL, 3 mg/kg iv), a nonselective antagonist, was given to nonpreconditioned s 10 m before the 30-m occlusion period. Fally, NL was admistered 10 m before preconditiong (NL + PC, group IV) or immediately after the last 5-m preconditiong period (PC + NL, group V). farct size (IS) as a percentage of the area at risk (AAR) (ISAAR) was determed by 2,3,5-triphenyltetrazolium chloride stag. PC resulted a marked reduction myocardial IS from 45 * 5 to 8 * 1 (P < 0.05). NL treatment before or immediately after PC abolished this protective effect; however, NL had no effect on IS non-PC important myocardial s.
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: May 1, 1995
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