Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts

Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts Schultz, Jo El J., Elana Rose, Zhenhai Yao, Garrett J. Gross. Evidence for volvement of preconditiong s. Am. J. PhysioZ. 268 ( Circ. PhysioZ. 37): H2157-H2161, 1995.-The purpose of the present study was to vestigate a possible role of preconditiong (PC). To test this hypothesis, anesthetized, open-chest, male Wistar s were subjected to five different protocols. group I, the control group was subjected to 30 m of left coronary artery occlusion 2 h of reperfusion. group II, PC was elicited by three 5m occlusion periods terspersed with 5 m of reperfusion. group III, naloxone (NL, 3 mg/kg iv), a nonselective antagonist, was given to nonpreconditioned s 10 m before the 30-m occlusion period. Fally, NL was admistered 10 m before preconditiong (NL + PC, group IV) or immediately after the last 5-m preconditiong period (PC + NL, group V). farct size (IS) as a percentage of the area at risk (AAR) (ISAAR) was determed by 2,3,5-triphenyltetrazolium chloride stag. PC resulted a marked reduction myocardial IS from 45 * 5 to 8 * 1 (P < 0.05). NL treatment before or immediately after PC abolished this protective effect; however, NL had no effect on IS non-PC important myocardial s. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts

Loading next page...
 
/lp/the-american-physiological-society/evidence-for-involvement-of-opioid-receptors-in-ischemic-5gS0DokqVo
Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

Schultz, Jo El J., Elana Rose, Zhenhai Yao, Garrett J. Gross. Evidence for volvement of preconditiong s. Am. J. PhysioZ. 268 ( Circ. PhysioZ. 37): H2157-H2161, 1995.-The purpose of the present study was to vestigate a possible role of preconditiong (PC). To test this hypothesis, anesthetized, open-chest, male Wistar s were subjected to five different protocols. group I, the control group was subjected to 30 m of left coronary artery occlusion 2 h of reperfusion. group II, PC was elicited by three 5m occlusion periods terspersed with 5 m of reperfusion. group III, naloxone (NL, 3 mg/kg iv), a nonselective antagonist, was given to nonpreconditioned s 10 m before the 30-m occlusion period. Fally, NL was admistered 10 m before preconditiong (NL + PC, group IV) or immediately after the last 5-m preconditiong period (PC + NL, group V). farct size (IS) as a percentage of the area at risk (AAR) (ISAAR) was determed by 2,3,5-triphenyltetrazolium chloride stag. PC resulted a marked reduction myocardial IS from 45 * 5 to 8 * 1 (P < 0.05). NL treatment before or immediately after PC abolished this protective effect; however, NL had no effect on IS non-PC important myocardial s.

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: May 1, 1995

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off