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Endurance training enhances lactate clearance during hyperlactatemia

Endurance training enhances lactate clearance during hyperlactatemia DONOVAN, CASEY M., AND MICHAEL J. PAGLIASSOTTI. Endurance during hypermia. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E782E789,1989.-Constant infusions of cold molar (178.0 t 1.6 pmol . kg-l. min-l), [U-14C] (0.50 &i/min), and [6“HIglucose (0.5 &i/min) were employed to study the effects of endurance (running 1 h /day, at 38 m/min, 10% grade) on in resting, hypermic rats. Before infusion, resting blood levels were not significantly different between controls, 1.10 t 0.04 mM, and trained animals, 1.16 t 0.04 mM. levels increased significantly during the infusion period, attaining steady-state mixed venous concentrations of 11.32 & 0.24 mM and 5.44 t 0.09 mM, respectively, for controls and trained animals. rates, based on net removal (i.e., not tracer-estimated removal), were twofold greater in trained animals vs. controls, 33.0 t 0.7 and 15.4 t 0.4 ml. kg-’ .min-l, respectively. specific activity values during the infusion period were not significantly different between controls, 22,243 t 236 dpm/pmol, and trained animals, 21,270 t 374 dpm/pmol, indicating similar endogenous dilution of the pyruvate- pool. For both control and trained animals, essentially 100% of the 14C infused as was recovered as either glucose or CO,; however, trained animals demonstrated a 25% greater rate of gluconeogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Endurance training enhances lactate clearance during hyperlactatemia

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Publisher
The American Physiological Society
Copyright
Copyright © 1989 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
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Abstract

DONOVAN, CASEY M., AND MICHAEL J. PAGLIASSOTTI. Endurance during hypermia. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E782E789,1989.-Constant infusions of cold molar (178.0 t 1.6 pmol . kg-l. min-l), [U-14C] (0.50 &i/min), and [6“HIglucose (0.5 &i/min) were employed to study the effects of endurance (running 1 h /day, at 38 m/min, 10% grade) on in resting, hypermic rats. Before infusion, resting blood levels were not significantly different between controls, 1.10 t 0.04 mM, and trained animals, 1.16 t 0.04 mM. levels increased significantly during the infusion period, attaining steady-state mixed venous concentrations of 11.32 & 0.24 mM and 5.44 t 0.09 mM, respectively, for controls and trained animals. rates, based on net removal (i.e., not tracer-estimated removal), were twofold greater in trained animals vs. controls, 33.0 t 0.7 and 15.4 t 0.4 ml. kg-’ .min-l, respectively. specific activity values during the infusion period were not significantly different between controls, 22,243 t 236 dpm/pmol, and trained animals, 21,270 t 374 dpm/pmol, indicating similar endogenous dilution of the pyruvate- pool. For both control and trained animals, essentially 100% of the 14C infused as was recovered as either glucose or CO,; however, trained animals demonstrated a 25% greater rate of gluconeogenesis.

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Nov 1, 1989

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