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DONOVAN, CASEY M., AND MICHAEL J. PAGLIASSOTTI. Endurance during hypermia. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E782E789,1989.-Constant infusions of cold molar (178.0 t 1.6 pmol . kg-l. min-l), [U-14C] (0.50 &i/min), and [6âHIglucose (0.5 &i/min) were employed to study the effects of endurance (running 1 h /day, at 38 m/min, 10% grade) on in resting, hypermic rats. Before infusion, resting blood levels were not significantly different between controls, 1.10 t 0.04 mM, and trained animals, 1.16 t 0.04 mM. levels increased significantly during the infusion period, attaining steady-state mixed venous concentrations of 11.32 & 0.24 mM and 5.44 t 0.09 mM, respectively, for controls and trained animals. rates, based on net removal (i.e., not tracer-estimated removal), were twofold greater in trained animals vs. controls, 33.0 t 0.7 and 15.4 t 0.4 ml. kg-â .min-l, respectively. specific activity values during the infusion period were not significantly different between controls, 22,243 t 236 dpm/pmol, and trained animals, 21,270 t 374 dpm/pmol, indicating similar endogenous dilution of the pyruvate- pool. For both control and trained animals, essentially 100% of the 14C infused as was recovered as either glucose or CO,; however, trained animals demonstrated a 25% greater rate of gluconeogenesis.
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Nov 1, 1989
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