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Effects of tolbutamide on gluconeogenesis and glycolysis in isolated perfused rat liver

Effects of tolbutamide on gluconeogenesis and glycolysis in isolated perfused rat liver AJP - Endocrinology and Metabolism publishes results of original studies about endocrine and metabolic systems on any level of organization. It is published 12 times a year (monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright © 1986 by the American Physiological Society. ISSN: 0193-1849, ESSN: 1522-1555. Visit our website at http://www.the-aps.org/. TARUN B. PATEL Department of Pharmacology, University of Tennessee Center for the Health Sciences College of Medicine, Memphis, Tennessee 38163 PATEL, TARUN B. s on and glycolysis in isolated perfused rat liver. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E82-E86, 1986.-In isolated perfused livers of 24-h fasted rats, perfused with lactate (2 mM), pyruvate (0.5 mM), or dihydroxyacetone (1 mM), infusion (0.5 mM) very rapidly (within 3 min) inhibited the rate of . However, from fructose (1 mM) and glycerol (1 mM) was not affected by tolbutamide. Tolbutamide also inhibited by 30% the rate of 14C02 production from livers perfused with [ 1-14C]pyruvate, without altering the rate of 14C02 production from [Z-14C]pyruvate. The rate of hepatic glycolysis from fructose, glycerol, and dihydroxyacetone was also stimulated by 250,40, and lOO%, respectively, during tolbutamide infusion into perfused livers. Tolbutamide also inhibited the endogenous rate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Effects of tolbutamide on gluconeogenesis and glycolysis in isolated perfused rat liver

T. B. Patel
AJP - Endocrinology and Metabolism , Volume 250: E82 – Jan 1, 1986
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Publisher
The American Physiological Society
Copyright
Copyright © 1986 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
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Abstract

AJP - Endocrinology and Metabolism publishes results of original studies about endocrine and metabolic systems on any level of organization. It is published 12 times a year (monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright © 1986 by the American Physiological Society. ISSN: 0193-1849, ESSN: 1522-1555. Visit our website at http://www.the-aps.org/. TARUN B. PATEL Department of Pharmacology, University of Tennessee Center for the Health Sciences College of Medicine, Memphis, Tennessee 38163 PATEL, TARUN B. s on and glycolysis in isolated perfused rat liver. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E82-E86, 1986.-In isolated perfused livers of 24-h fasted rats, perfused with lactate (2 mM), pyruvate (0.5 mM), or dihydroxyacetone (1 mM), infusion (0.5 mM) very rapidly (within 3 min) inhibited the rate of . However, from fructose (1 mM) and glycerol (1 mM) was not affected by tolbutamide. Tolbutamide also inhibited by 30% the rate of 14C02 production from livers perfused with [ 1-14C]pyruvate, without altering the rate of 14C02 production from [Z-14C]pyruvate. The rate of hepatic glycolysis from fructose, glycerol, and dihydroxyacetone was also stimulated by 250,40, and lOO%, respectively, during tolbutamide infusion into perfused livers. Tolbutamide also inhibited the endogenous rate

Journal

AJP - Endocrinology and Metabolism – The American Physiological Society

Published: Jan 1, 1986

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