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Effects of salicylates on exercise metabolism

Effects of salicylates on exercise metabolism Abstract Some metabolic effects of salicylates were measured on ten normal young males steadily performing controlled moderate exercise after administration of acetyl salicylic acid (ASA). Dosages at a rate up to 4.8 g/day were administered over lengthening periods, the last dose 1frac12–2 hr before walking on a power-driven treadmill in a temperature-controlled room. Oxygen consumption was measured, as were pulmonary ventilation, pulse rate, and blood lactic acid. While analysis of results indicated increase in resting O 2 consumption within 2 hr of the first dose, no modification of O 2 consumption of exercise appeared. Pulmonary ventilation was not increased after one dose, but did increase at rest, during exercise, and recovery after longer dosage; O 2 extraction from each unit of ventilation increased after one dose at rest and during exercise; the extraction ratio was still increased at rest after longer administration of ASA, but decreased during exercise and recovery. Increased ventilation was predominantly effected by increased depth of respiration rather than by changes in rate. Pulse rates were not changed and no significant effects on the cardiovascular system were discerned in this respect. Submitted on March 10, 1962 Copyright © 1962 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Effects of salicylates on exercise metabolism

Downey, John A.; Darling, Robert C.
Journal of Applied Physiology , Volume 17 (4): 665 – Jul 1, 1962
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Publisher
The American Physiological Society
Copyright
Copyright © 1962 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
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Abstract

Abstract Some metabolic effects of salicylates were measured on ten normal young males steadily performing controlled moderate exercise after administration of acetyl salicylic acid (ASA). Dosages at a rate up to 4.8 g/day were administered over lengthening periods, the last dose 1frac12–2 hr before walking on a power-driven treadmill in a temperature-controlled room. Oxygen consumption was measured, as were pulmonary ventilation, pulse rate, and blood lactic acid. While analysis of results indicated increase in resting O 2 consumption within 2 hr of the first dose, no modification of O 2 consumption of exercise appeared. Pulmonary ventilation was not increased after one dose, but did increase at rest, during exercise, and recovery after longer dosage; O 2 extraction from each unit of ventilation increased after one dose at rest and during exercise; the extraction ratio was still increased at rest after longer administration of ASA, but decreased during exercise and recovery. Increased ventilation was predominantly effected by increased depth of respiration rather than by changes in rate. Pulse rates were not changed and no significant effects on the cardiovascular system were discerned in this respect. Submitted on March 10, 1962 Copyright © 1962 the American Physiological Society

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Jul 1, 1962

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