Hirai, Tadakazu, Mark D. Visneski, Kevin J. Kearns, Robert Zelis, and Timothy I. Musch. Effects of on the muscular blood flow response to treadmill in rats. J. Appl. Physiol. 77(3): 1288-1293, 1994.The functional role of nitric oxide () release in regulating blood flow (BF) to exercising skeletal muscle was studied in conscious male Sprague-Dawley rats (603 t 28 g; n = 6). In this study, BF was measured using radiolabeled microspheres treadmill (10% grade, 20 m/min) before and after (S) with NG-nitro-L-arginine methyl ester (30 mg/kg ia). After S , mean arterial blood pressure increased from resting baseline values and the duration of vasodilator responses to acetylcholine (ACh) injections (3.0 and 10.0 pg/kg ia) was diminished (P < 0.05), demonstrating reduced S function. , BF to the kidneys and organs of the gut was reduced after S . In addition, BF was reduced in 16 of the 28 individual hindquarter muscles or muscle parts. Moreover these reductions in BF were linearly correlated with the estimated sum of the percentage of fast-twitch oxidative glycolytic (FOG) and slow-twitch oxidative (SO) types of fibers found in each muscle [ABF = -l.l(%SO + %FOG) + 16.4; r = 0.88, P < O.OOl].
Journal of Applied Physiology – The American Physiological Society
Published: Sep 1, 1994
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