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Effects of mechanical limitation of apical rotation on left ventricular relaxation and end-diastolic pressure

Abstract Left ventricular (LV) twist is thought to play an important role in cardiac function. However, how twist affects systolic or diastolic function is not understood in detail. We acquired apical and basal short-axis images of dogs undergoing open-chest procedures ( n = 15) using a GE Vivid 7 at baseline and during the use of an apical suction device (Starfish) to limit apical rotation. We measured LV pressure and stroke volume using a micromanometer-tipped catheter and an ultrasonic flow probe, respectively. Peak radial strain, peak rotation, peak twist, peak systolic twisting rate (TR), peak untwisting rate during isovolumic relaxation period (UR IVR ), and peak early diastolic untwisting rate after mitral valve opening (UR E ) were determined using speckle tracking echocardiography. Immobilizing the apex with gentle suction significantly decreased apical rotation (−50 ± 27%) and slightly increased basal rotation, resulting in a significant decrease in twist. The time constant of LV relaxation (τ) was prolonged, and LV end-diastolic pressure increased. TR and UR IVR decreased. LV systolic pressure, peak positive and negative first derivative of LV pressure (±dP/d t ), stroke volume, radial strain, and UR E were not changed. The correlation between τ and UR IVR ( r = 0.63, P = 0.0006) was stronger than that between peak +dP/d t and TR ( r = 0.46, P = 0.01). Diastolic function was impaired with reduced apical rotation and UR IVR when the apex of the heart was immobilized using an apical suction device. echocardiography hemodyamics speckle tracking Copyright © 2011 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print July 2011 , doi: 10.​1152/​ajpheart.​00316.​2011 AJP - Heart October 2011 vol. 301 no. 4 H1456-H1460 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpheart.00316.2011v1 301/4/H1456 most recent Classifications Muscle Mechanics and Ventricular Function Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Iwasaki, M. Articles by Nakatani, S. PubMed PubMed citation Articles by Iwasaki, M. Articles by Nakatani, S. Related Content Load related web page information Current Issue October 2011, 301 (4) Alert me to new issues of AJP - Heart About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2011 the American Physiological Society Print ISSN: 0363-6135 Online ISSN: 1522-1539 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

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