Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effects of forebrain circumventricular organ ablation on drinking or salt appetite after sodium depletion or hypernatremia

Effects of forebrain circumventricular organ ablation on drinking or salt appetite after sodium... In many previous studies, one or the other forebrain circumventricular organ, the subfornical organ (SFO) or organum vasculosum laminae terminalis (OVLT), was lesioned to test whether it was critical for the behavioral or physiological responses to sodium depletion and hypernatremia. These studies conflict in their conclusions. The present study was designed to create discrete lesions of both the SFO and OVLT in the same animals and to compare these with rats having a lesion of only the SFO or OVLT. Both the OVLT-lesioned group and the combined SFO + OVLT-lesioned group drank significantly more water and saline on a daily basis than Controls or SFO-lesioned rats. In both sodium depletion and hypertonic saline testing, rats with SFO lesions displayed transient deficits in salt appetite or thirst responses, whereas the rats with single OVLT lesions did not. In the sodium depletion test, but not in the hypernatremia test, rats with lesions of both the SFO and OVLT exhibited the largest deficit. The data support the hypothesis that a combined lesion eliminates redundancy and is more effective than a single lesion in sodium depletion tests. The interpretation of the OVLT lesion-only data may have been complicated by a tendency to drink more fluid on a daily basis, because some of those animals drank copious water in addition to saline even very early during the salt appetite test. subfornical organ; organum vasculosum laminae terminalis; osmoregulation; hypovolemia; rats Address for reprint requests and other correspondence: D. A. Fitts, Dept. of Psychology, Univ. of Washington, Box 351525, Seattle, WA 98195–1525 (E-mail: dfitts@u.washington.edu ) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Effects of forebrain circumventricular organ ablation on drinking or salt appetite after sodium depletion or hypernatremia

Download PDF
11 pages

Loading next page...
 
/lp/the-american-physiological-society/effects-of-forebrain-circumventricular-organ-ablation-on-drinking-or-Z7k0RjTLpr

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
DOI
10.1152/ajpregu.00391.2004
pmid
15308489
Publisher site
See Article on Publisher Site

Abstract

In many previous studies, one or the other forebrain circumventricular organ, the subfornical organ (SFO) or organum vasculosum laminae terminalis (OVLT), was lesioned to test whether it was critical for the behavioral or physiological responses to sodium depletion and hypernatremia. These studies conflict in their conclusions. The present study was designed to create discrete lesions of both the SFO and OVLT in the same animals and to compare these with rats having a lesion of only the SFO or OVLT. Both the OVLT-lesioned group and the combined SFO + OVLT-lesioned group drank significantly more water and saline on a daily basis than Controls or SFO-lesioned rats. In both sodium depletion and hypertonic saline testing, rats with SFO lesions displayed transient deficits in salt appetite or thirst responses, whereas the rats with single OVLT lesions did not. In the sodium depletion test, but not in the hypernatremia test, rats with lesions of both the SFO and OVLT exhibited the largest deficit. The data support the hypothesis that a combined lesion eliminates redundancy and is more effective than a single lesion in sodium depletion tests. The interpretation of the OVLT lesion-only data may have been complicated by a tendency to drink more fluid on a daily basis, because some of those animals drank copious water in addition to saline even very early during the salt appetite test. subfornical organ; organum vasculosum laminae terminalis; osmoregulation; hypovolemia; rats Address for reprint requests and other correspondence: D. A. Fitts, Dept. of Psychology, Univ. of Washington, Box 351525, Seattle, WA 98195–1525 (E-mail: dfitts@u.washington.edu )

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: Dec 1, 2004

There are no references for this article.