656 0161-7567/92 $2.00 Copyright dysfunction (31). Scarring does not take place a single insult (9, 31). The repair process the may even result in an improved resistance to subsequent damage (4). Despite the familiarity these symptoms, the exact pathophysiology underlying -induced injury remains uncertain. Measurement serum creatine kinase (CK) activity is a common method for determining injury. Eccentric lengthening causes a large delayed increase in CK activity. However, concentric shortening results in a small or even no increase in CK activity. Peak values then usually occur within the first 24 h (4). Clarkson Tremblay (3) recently hypothesized that the loss sarcolemmal integrity accompanied by a release CK marks the final stage fiber necrosis. An -induced release CK (a predominantly cytoplasmic enzyme), however, can be due to either temporary fiber damage accompanied by membrane leakage or final death the fiber. Although animal studies on the effect eccentric reveal fiber necrosis (1,16), histological examinations loaded tissue in humans are contradictory. Jones et al. (17) reported degenerating fibers, infiltration by mononuclear cells, eventually signs regeneration in late biopsies the affected s. Stauber et al. (32) found extracellular matrix disruption a few necrotic fibers in, human biopsies obtained 48 h eccentric the
Journal of Applied Physiology – The American Physiological Society
Published: Feb 1, 1992
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