Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effects of central stimulants on onset of diaphragm activity during breath holding

Effects of central stimulants on onset of diaphragm activity during breath holding Abstract The effect of d -methylamphetamine, caffeine, and analeptics on the alveolar Pco 2 during spontaneous breathing and at the onset of diaphragm activity during breath holding has been studied. After d -methylamphetamine the value of alveolar Pco 2 at the onset of diaphragm activity, as well as at the breaking point, is significantly increased, while the ventilation-alveolar Pco 2 relationship is not changed. After caffeine the value of the alveolar Pco 2 at the onset of diaphragm activity, as well as at the breaking point, is significantly decreased and the ventilation-alveolar Pco 2 relationship is significantly shifted to a lower Pco 2 . The value of alveolar Pco 2 at onset of diaphragm activity is significantly decreased by prethcamide, increased by pentylenetetrazol, and not affected by dimefline. The ventilation-alveolar Pco 2 relationship was not changed by such analeptics. These data, together with those previously obtained on hypoxia, suggest that factors changing the ventilation-alveolar Pco 2 relationship also affect the onset of diaphragm activity, while the onset of diaphragm activity can be changed without affecting the ventilatory response to CO 2 . effect of analeptics on breath holding and on CO 2 response curve; breaking point of breath holding; effect of caffeine on breath holding and on CO 2 response curve; effect of d-methylamphetamine on breath holding and on CO 2 response curve; ventilation-alveolar Pco 2 relationship Submitted on July 5, 1963 Copyright © 1964 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Effects of central stimulants on onset of diaphragm activity during breath holding

Download PDF
5 pages

Loading next page...
 
/lp/the-american-physiological-society/effects-of-central-stimulants-on-onset-of-diaphragm-activity-during-Y6MgrQ4KIt

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 1964 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
See Article on Publisher Site

Abstract

Abstract The effect of d -methylamphetamine, caffeine, and analeptics on the alveolar Pco 2 during spontaneous breathing and at the onset of diaphragm activity during breath holding has been studied. After d -methylamphetamine the value of alveolar Pco 2 at the onset of diaphragm activity, as well as at the breaking point, is significantly increased, while the ventilation-alveolar Pco 2 relationship is not changed. After caffeine the value of the alveolar Pco 2 at the onset of diaphragm activity, as well as at the breaking point, is significantly decreased and the ventilation-alveolar Pco 2 relationship is significantly shifted to a lower Pco 2 . The value of alveolar Pco 2 at onset of diaphragm activity is significantly decreased by prethcamide, increased by pentylenetetrazol, and not affected by dimefline. The ventilation-alveolar Pco 2 relationship was not changed by such analeptics. These data, together with those previously obtained on hypoxia, suggest that factors changing the ventilation-alveolar Pco 2 relationship also affect the onset of diaphragm activity, while the onset of diaphragm activity can be changed without affecting the ventilatory response to CO 2 . effect of analeptics on breath holding and on CO 2 response curve; breaking point of breath holding; effect of caffeine on breath holding and on CO 2 response curve; effect of d-methylamphetamine on breath holding and on CO 2 response curve; ventilation-alveolar Pco 2 relationship Submitted on July 5, 1963 Copyright © 1964 the American Physiological Society

Journal

Journal of Applied Physiology – The American Physiological Society

Published: May 1, 1964

There are no references for this article.