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Effects of a monoclonal antibody directed against P-selectin after myocardial ischemia and reperfusion

Effects of a monoclonal antibody directed against P-selectin after myocardial ischemia and... ADHESION H88 0363-6135/96 $5.00 Copyright o 1996 (13, 14, 19-22). The selectin family of adhesion molecules, including L-selectin, E-selectin, and P-selectin as well as the sialyl LewisX blood antigen, modulate rolling of PMNs along the endothelium before their firm adhesion (10, 27). Mulligan and co-workers (24) reported that P-selectin is essential for the expression of neutrophil-dependent lung in rats after complement activation with cobra venom factor. Another study by Winn et al. (34) reported that an antP-selectin MAb significantly reduced reperfusion to the rabbit ear. P-selectin has also been implicated in myocardial in the feline heart subjected to coronary artery ischemia and reperfusion. Weyrich et al. (33) observed prominent P-selectin immunostaining in the cytoplasm of the cat coronary endothelium after 90 min of coronary artery occlusion and 20 min of reperfusion. This study also demonstrated that immunoneutralization of P-selectin with MAb PB1.3 at the time of reperfusion preserved coronary endothelial nitric oxide release and attenuated myocardial cell necrosis after 4.5 h of reperfusion. At present, the effects of P-selectin inhibition on postischemic myocardial blood flow and contractile function have not been determined. Accordingly, the purpose of the present study was to investigate the effects of a MAb directed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Effects of a monoclonal antibody directed against P-selectin after myocardial ischemia and reperfusion

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Publisher
The American Physiological Society
Copyright
Copyright © 1996 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

ADHESION H88 0363-6135/96 $5.00 Copyright o 1996 (13, 14, 19-22). The selectin family of adhesion molecules, including L-selectin, E-selectin, and P-selectin as well as the sialyl LewisX blood antigen, modulate rolling of PMNs along the endothelium before their firm adhesion (10, 27). Mulligan and co-workers (24) reported that P-selectin is essential for the expression of neutrophil-dependent lung in rats after complement activation with cobra venom factor. Another study by Winn et al. (34) reported that an antP-selectin MAb significantly reduced reperfusion to the rabbit ear. P-selectin has also been implicated in myocardial in the feline heart subjected to coronary artery ischemia and reperfusion. Weyrich et al. (33) observed prominent P-selectin immunostaining in the cytoplasm of the cat coronary endothelium after 90 min of coronary artery occlusion and 20 min of reperfusion. This study also demonstrated that immunoneutralization of P-selectin with MAb PB1.3 at the time of reperfusion preserved coronary endothelial nitric oxide release and attenuated myocardial cell necrosis after 4.5 h of reperfusion. At present, the effects of P-selectin inhibition on postischemic myocardial blood flow and contractile function have not been determined. Accordingly, the purpose of the present study was to investigate the effects of a MAb directed

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Jan 1, 1996

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